2011 Polyamines Gordon Research Conference and Gordon Research Seminar

描述（由申请人提供）：自1975年以来，戈登多胺研究会议（GRC）是一个多学科会议，重点关注多胺代谢途径，多胺在细胞生理学中的作用以及调节多胺代谢的小分子作为潜在治疗剂的发展。这次会议被广泛认为是介绍和讨论多胺研究的最佳场所。Polyamines GRC将于2011年6月19日至24日在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行。多胺是几乎在所有原核和真核细胞中发现的小有机多阳离子。多年来，人们已经认识到多胺及其酶在多种人类疾病中发挥着关键作用。近年来，越来越清楚的是，多胺在不同的生物体中具有独特的作用，并且生物合成和分解代谢途径以及相关的调节机制在物种之间差异很大。因此，该领域汇集了对多胺在多种生物（哺乳动物细胞、酵母、原生动物和细菌）中的生理作用感兴趣的研究人员，以及对癌症、寄生虫或细菌感染的治疗应用感兴趣的研究人员。多胺GRC所代表的各种科学学科为参与者提供了一个智力刺激的环境。2011年的会议将邀请多胺研究前沿的科学家发表演讲。演讲者将强调多胺在致癌、能量代谢疾病和寄生虫发病中的作用。会议将包括关于抗癌和抗寄生虫药物开发以及疾病模型的介绍，以弥合基础研究和转化研究之间的差距。其他会议旨在促进表观遗传学领域的讨论，这可能会深入了解多胺调节细胞生长的基本机制，并概述多胺代谢在各种生物体的细胞稳态中的作用。会议将包括30分钟的演讲和10分钟的讨论时间，以及两次海报会议。它还将包括学生或博士后的简短演讲，他们的作品已经从海报演讲中选择出来。为了进一步鼓励青年科学家的参与，多胺GRC将与第三届多胺研究生研究研讨会（GRS）一起举行。GRS的主要目标将再次是为研究生和博士后提供一个轻松的氛围，鼓励在除了少数资深同事之外的所有人都缺席的情况下自由交流科学信息。在过去的几年里，这使得随后的GRC经历更加丰富而不那么令人生畏，这些年轻科学家在主要会议期间的讨论阶段的大量参与证明了这一点。我们期待这两个会议的参与者之间的互动将促进研究工具和思想的分享，从而加强当前的合作并培育新的合作。

DESCRIPTION (provided by applicant): Since 1975, the Gordon Research Conference (GRC) on Polyamines has been a multidisciplinary conference focused on the polyamine metabolic pathway, the role of polyamines in cellular physiology and the development of small molecules that modulate polyamine metabolism as potential therapeutic agents. This meeting is widely regarded as the pre-eminent venue for the presentation and discussion of polyamine research. The Polyamines GRC will be held at the Waterville Valley Resort in Waterville Valley, NH from June 19-24, 2011. Polyamines are small organic polycations found in virtually all prokaryotic and eukaryotic cells. It has been acknowledged for many years that the polyamines and their enzymes play critical roles in a diverse set of human diseases. In recent years, it has become increasingly clear that polyamines have unique roles in different organisms, and further that the biosynthetic and catabolic pathways, as well as the associated regulatory mechanisms, vary widely among species. Thus, the field brings together researchers interested in the physiological role of polyamines in a broad array of organisms (mammalian cells, yeast, protozoa and bacteria) and researchers interested in therapeutic applications for cancer and parasitic or bacterial infection. This variety of scientific disciplines represented at the Polyamines GRC makes for an intellectually stimulating environment for participants. The 2011 conference will feature presentations from scientists in the forefront of polyamine research. Speakers will emphasize the role of the polyamines in carcinogenesis, diseases of energy metabolism and parasite pathogenesis. The meeting will include presentations on anticancer and antiparasitic drug development, as well as disease models to bridge the gap between basic and translational research. Other sessions have been designed to promote discussion in the area of epigenetics, which may give insight into the basic mechanisms by which polyamines regulate cell growth, and to outline the role of polyamine metabolism in cellular homeostasis in a variety of organisms. The meeting will be composed of 30 minute talks followed by 10 minute discussion periods, and two poster sessions. It will also include short talks by students or postdoctoral fellows whose work has been chosen from the poster presentations. To further encourage the participation of young scientists, the Polyamines GRC will be held in conjunction with the third Graduate Research Seminar (GRS) on Polyamines. The main objective of the GRS will again be to provide graduate students and postdoctoral fellows with a relaxed atmosphere that encourages free exchange of scientific information in the absence of all but a few senior colleagues. In previous years this has made the GRC that follows a richer and less intimidating experience, as evidenced by significant participation of these young scientists in discussion periods during the main conference. We anticipate that the interactions between participants of both conferences will promote the sharing of research tools and ideas, consequently strengthening current collaborations and fostering new ones. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE The Gordon Research Conference on Polyamines and the pre-conference Graduate Research Seminar provide a forum for both internationally known researchers and young scientists new to the field to discuss their work and maintain active scientific collaborations. Our goal is to promote discussion from a diverse scientific community on the mechanisms that link the polyamines and their enzymes to human disease. The Gordon Conferences provide the ideal setting, with a format emphasizing the presentation of new and unpublished material in an informal and interactive setting that encourages extensive discussion.