FASEB SRC on Signal Transduction in the Immune System

申请者描述(由申请者提供)：本申请寻求为2011年6月19-24日在科罗拉多州斯诺马斯举行的FASEB夏季会议“免疫系统中的信号转导”提供部分资金，未来的会议将于2013年和2015年举行。本次会议的主要目标是全面关注在健康和疾病中涉及免疫细胞反应的信号机制的最新进展。2011年的会议将是本次FASEB会议的第6次。这次会议引起了研究机构、学术界和工业界的广泛兴趣，因为有出色的演讲者名单，所做工作的尖端性质，以及许多演讲与免疫学疾病的相关性。此外，由于大多数主流免疫学会议不提供对信号转导机制的深入关注，这次专门的FASEB会议将会议确立为许多研究人员的一个备受瞩目的论坛。因此，这次FASEB会议一直是FASEB夏季会议中出席人数最多的会议之一。这次会议吸引了世界各地免疫信号转导领域的领导者，以及新的研究人员和学生。计划于2011年举行的会议包括联合强调适应性和先天免疫信号机制，使该计划在免疫学会议中独一无二，特别是在专注于信号传递的会议中。2011年的会议重点关注调节白细胞激活和迁移的细胞骨架变化，淋巴细胞分化过程中代谢途径的重要性，以及使用显微镜和数学模型来揭示白细胞受体信号和激酶调节的详细生化机制。这些主题代表了免疫信号研究的前沿，使拟议的计划相对于其他会议来说是独一无二的。虽然会议有一批定期与会者和演讲者，但我们将确保在2011年通过22位新的演讲者(33场特邀演讲中的22位)来讨论新的想法和领域。此外，每一次会议都有空间从摘要中选择一次或几次简短的演讲，优先考虑新的调查人员或没有介绍个人信息的团体的博士后。这将确保会议议题的多样性。会议的总体目标是：1.对免疫信号的最新进展进行批判性和深入的概述，重点是白细胞迁移和新陈代谢以及利用尖端技术解决这些问题；2.将资深科学家和年轻研究人员聚集在一起，在愉快的陈述和非正式讨论的气氛中促进学生和年轻研究人员的技能；3.通过广泛传播信息和最新突破，迅速推进免疫系统分子机制的研究。因此，我们预计这次会议将建立在以往会议的成功基础上，影响免疫信号研究的方向。 公共卫生相关性：本次会议的主要目标是全面关注在健康和疾病中涉及免疫细胞反应的信号机制的最新进展。大量的人类疾病影响信号转导通路中的分子，因此，这些通路为越来越多涉及免疫系统和炎症的疾病提供了潜在的治疗靶点。这次会议将通过广泛传播信息和该领域的最新突破，为免疫系统研究的快速发展做出贡献。此外，这次会议将提供一个论坛，热烈讨论新的想法及其对开发治疗炎症性和自身免疫性疾病以及癌症的新疗法的适用性。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System", to be held June 19-24, 2011 in Snowmass, Colorado, with future meetings to be held in 2013 and 2015. The major goal of this conference is to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the response of immune cells in both health and disease. The meeting in 2011 will be the 6th occurrence of this FASEB conference. This conference has garnered widespread interest in research institutes, academia, and industry because of the outstanding speaker rosters, the cutting edge nature of the work presented and the relevance of many presentations to immunologic diseases. Additionally, since most mainstream immunology meetings do not provide an in-depth focus on signal transduction mechanisms, this dedicated FASEB conference has established the meeting as a high profile forum for many investigators. As a result, this FASEB conference has been one of the most highly attended FASEB Summer conferences in general. The meeting attracts the leaders in immune signal transduction world-wide, as well as new investigators and students. The meeting planned for 2011 includes a joint emphasis on adaptive and innate immune signaling mechanisms, making this program unique among immunology meetings, and in particular, among meetings focusing on signaling. The 2011 conference includes a strong focus on cytoskeletal changes that regulate leukocyte activation and migration, the importance of metabolic pathways during lymphocyte differentiation, and the use of microscopy and mathematical modeling to uncover detailed biochemical mechanisms of leukocyte receptor signaling and kinase regulation. These topics represent the cutting edge of research in immune signaling, and make the proposed program unique relative to other meetings. Though the conference has a backbone of regular attendees and speakers, we will ensure that new ideas and areas are addressed in 2011 by featuring 22 new speakers (out of a total of 33 invited talks). In addition, each session has space for one or several short talks to be selected from abstracts, with priority given to new investigators or post-docs from groups in which PIs are not presenting. This will ensure a diversity of topics at the meeting. The overall objectives of the meeting are: 1. To provide a critical and intensive overview of the recent advances in immune signaling, emphasizing leukocyte migration and metabolism and the use of cutting edge technologies to address these issues; 2. To bring together senior scientists and young investigators in a convivial atmosphere of presentation and informal discussion to promote the skills of students and young investigators; 3. To rapidly advance the research on the molecular mechanisms in the immune system by broadly disseminating information and recent breakthroughs. Thus, we anticipate that this conference will build upon the success of past conferences in influencing the direction of immune signaling research. PUBLIC HEALTH RELEVANCE: The major goal of this conference is to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the response of immune cells in both health and disease. A large number of human diseases affect molecules in signal transduction pathways and thus, these pathways present potential therapeutic targets for the increasing number of diseases involving the immune system and inflammation. This conference will contribute to the rapid advancement of research on the immune system by broadly disseminating information and recent breakthroughs in the field. In addition, this conference will provide a forum for lively discussions of new ideas and their applicability to the development of novel therapeutics to treat inflammatory and autoimmune disorders, as well as cancer.