2011 Gordon Research Conference: Cellular and Molecular Mechanisms of Toxicity

描述(申请人提供)：2011年GRC-CMMOT：理解后基因组时代的创新机制毒理学摘要：基础分子毒理学继续支撑环境、制药和工业科学的关键创新。全球对药品和环境暴露的监管以及公众对风险的看法正在发生很大变化。为了迎接这些挑战，这一领域的发展科学需要保持在法规、政治和立法的领先地位。因此，这次会议将展示支持环境、制药和工业科学关键创新的尖端机械毒理学研究，并预示着在寻求预测和规避药物和毒物不良反应方面的一个激动人心的时期。会议主题广泛，如炎症与修复/适应、时钟基因、表观基因组学、肝毒性、神经炎症性疾病、个体易感性/适应以及体内和体内预测毒理学的新模型。会议将汇集一批处于各自领域前沿的研究人员，并将为初级科学家和研究生提供机会，以海报形式介绍他们的工作，并与该领域的领导人交流意见。一些海报主持人将被选中进行简短的演讲。这次会议气氛热烈，有计划的讨论会议以及在下午和晚上举行非正式聚会的机会，为来自不同学科的科学家提供了集思广益的途径，并促进了所代表的不同研究领域的跨学科合作。 公共卫生相关性：2011 GRC：CMMOT叙述在过去的几年里，人们越来越关注环境暴露及其对人类健康的潜在影响，从哮喘到癌症。这次关于毒性的细胞和分子机制的会议集中在暴露评估方面的前沿进展，以及我们在理解与环境相关的人类疾病起源的关键细胞和分子事件方面的最新进展。拟议的会议将为那些领导各自研究领域的人提供一个独特的机会，分享他们的成果，讨论未来的方向，并共同努力，推动这一高度跨学科的科学领域的发展。

DESCRIPTION (provided by applicant): 2011 GRC-CMMOT: Understanding Innovative Mechanistic Toxicology in the Post-Genomic Era Abstract: Basic molecular toxicology continues to underpin key innovations in environmental, pharmaceutical and industrial sciences. Much is changing in global regulation of pharmaceutical and environmental exposures and also in public perception of risk. In order to meet these challenges, the developing science in this area needs to keep ahead of regulation, politics and legislation. Thus, this conference will present cutting edge mechanistic toxicological research underpinning key innovations in environmental, pharmaceutical and industrial sciences and heralds an exciting period in the quest to predict and circumvent adverse drug and toxicant reactions. The Conference will feature a wide range of topics, such as inflammation and repair/adaptation, clock genes, epigenomics, hepatotoxicity, neuroinflammatory diseases, individual susceptibility/adaptation together with new models of in silico and in vivo predictive toxicology. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. PUBLIC HEALTH RELEVANCE: 2011 GRC: CMMOT Narrative Over the past several years, there has been growing concern regarding environmental exposures and their potential impact on human health, from asthma to cancer. This conference on the cellular and molecular mechanisms of toxicity focuses on both cutting-edge advances in exposure assessment as well as the latest advancements in our understanding of key cellular and molecular events underlying the origins of environmentally-linked human disease. The proposed conference will represent a unique opportunity for those leading their respective research areas to share their results, discuss future directions, and forge collaborative efforts that would advance this highly interdisciplinary field of science.