5th International Conference on Epithelial Mesenchymal Transition

描述（由申请人提供）：本提案的具体目的是为来自美国的学术演讲者和学生参加第五届上皮-间充质转化国际会议的费用（旅行和住宿）获得部分资金。会议将于2011年10月10日至13日在新加坡的Biopolis中心举行，由上皮-间充质转化国际协会（TEMTIA）主持。会议的目标是1。将癌症，病理学和发展等不同学科的研究人员聚集在一起，讨论他们对EMT的观察，并探讨是否对该过程的重要组成部分达成共识。2.提供一个论坛，让学生和初级研究人员可以与高级研究人员互动，并展示自己在该领域的工作和想法。3.在国际上扩大EMT相关研究人员的可行的跨学科合作论坛，特别是与亚洲的联系。这将继续提供一个跨学科交流专门知识、试剂和技术的全球网络。4.在适当的跨学科国际期刊上及时发表关于EMT的细胞、分子和遗传方面的会议更新。 上皮-间充质转化（EMT）是胚胎中细胞从细胞片形成三维结构的基本细胞过程。在EMT期间，上皮细胞失去与相邻细胞的粘附，降解局部基底膜并侵入下层间质细胞外基质。在细胞水平，这一过程需要特定的信号转导元件、新基因转录、细胞骨架重组、细胞外基质分子和生长因子的分泌。在胚胎中，这一过程在原肠胚形成、神经嵴细胞形成、体节分解、胰岛形成、心脏瓣膜形成、脑组织和器官发生的其他几个领域中重复。在成人中，EMT作为伤口愈合的组成部分以及在癌症转移和组织纤维化的病理学中发生。 公共卫生相关性：美国学术界科学家需要旅行支助，参加一个科学会议，该会议汇集了研究人员，探讨发展癌症和器官纤维化中细胞入侵的共同方面。上皮间质转化的领域正在迅速扩大，会议将汇集通常不相交的群体。

DESCRIPTION (provided by applicant): The specific aim of this proposal is to obtain partial funding for the expenses (travel and lodging) for academic speakers and students from the USA to attend the Fifth International Meeting on Epithelial-Mesenchymal Transition. The meeting will be held Oct 10-13, 2011 in the Biopolis Center of Singapore under the auspices of the Epithelial-Mesenchymal Transition International Association (TEMTIA). The objectives of the meeting are to 1. Bring together investigators in the separate disciplines of cancer, pathology and development to discuss their observations on EMT and explore whether there is a consensus on important components of the process. 2. Provide a forum where students and junior investigators can interact with senior investigators and display their own work and ideas in the field. 3. Expand a viable co-operative cross- disciplinary forum of EMT-related researchers internationally, particularly with outreach to Asia. This will continue to provide a worldwide network for exchange of expertise, reagents and techniques across disciplines. 4. Publish a timely meeting update on cellular, molecular and genetic aspects of EMT in an appropriate cross-disciplinary international journal. Epithelial-mesenchymal transition (EMT) is a fundamental cellular process undertaken by cells in the embryo to form 3-dimensional structures from sheets of cells. During EMT, epithelial cells lose adherence to adjacent cells, degrade the local basement membrane and invade the underlying interstitial extracellular matrix. At the cellular level, this process requires specific signal transduction elements, new gene transcription, reorganization of the cytoskeleton, secretion of extracellular matrix molecules and growth factors. In the embryo, this process is reiterated at gastrulation, neural crest cell formation, somite breakdown, pancreatic islet formation, heart valve formation brain organization and in several other areas of organogenesis. In the adult, EMT occurs as a component of wound healing and in the pathologies of cancer metastasis and tissue fibrosis. PUBLIC HEALTH RELEVANCE: Support is requested for travel by academic US scientists to participate in a scientific meeting that brings together researchers exploring common aspects of cell invasion in development cancer and organ fibrosis. The field of epithelial mesenchymal transition is rapidly expanding and the conference will bring together groups who do not normally intersect.