2011 Epithelial Differentiation & Keratinization

描述(由申请者提供)：几十年来，戈登上皮分化和角质化研究会议一直是介绍和讨论上皮生物学研究的主要论坛。这次会议经常被超额认购，参加会议的有上皮生物学领域的顶尖国际科学家，以及更初级的研究人员、博士后研究员、学生和工业界的科学家。近年来，对表皮分化的最初关注已经扩大到包括一系列上皮生物学家感兴趣的主题，包括皮肤及其附件的发育生物学、干细胞和再生过程、表观遗传学、皮肤微生物组、皮肤免疫学以及表皮屏障在全身疾病中的作用。2009年的会议强调了毛囊生物学，2011年的会议将强调表皮，并涵盖了一系列上皮生物学研究的前沿课题。我们将包括研究视网膜、乳腺上皮和肠道等非表皮上皮的科学家，以及感兴趣的上皮以外的研究人员，以提供更多的见解，刺激创新方法，并确定新的研究领域。2011年的计划强调了表皮屏障的功能和功能障碍；干细胞的调节和治疗应用；炎症；以及形态发生。我们将继续并发扬我们的长期传统，即确定上皮生物学前沿最重要的问题和机会，并促进在该领域工作的科学家以及其他科学领域的领导者之间的互动和讨论。我们的目标是促进进入上皮生物学领域的年轻研究人员的发展，并鼓励来自代表性不足的少数族裔的科学家参与进来。为实现这些目标，2011年会议将汇集一批国际与会者，其中包括来自学术界、工业界、临床医生和基础研究人员的科学家、青年科学家和资深科学家、皮肤科医生和病理学家以及细胞、发育和分子生物学家，他们将在有利于自由交流思想的氛围中交流意见。“青年研究员奖”将颁发给最有前途的研究生和博士后水平的主持人，我们将为优秀的少数族裔申请者提供旅行奖学金。主要专题包括：1)不同上皮细胞的分化和疾病；2)表皮稳态和屏障功能；3)皮肤细胞的治疗应用；4)免疫系统在上皮生物学和疾病中的作用；5)皮肤干细胞；6)上皮形态发生；6)极性、黏附和细胞骨架；以及7)新的调节机制。此外，周三晚上的口头问题上升会议将突出提交的摘要，以确保该计划反映在提交本申请和会议之间出现的令人兴奋的新主题。这项提议的具体目标是筹集资金，以支持青年调查员奖以及会议主席和特邀发言者的旅行、登记和培训。

DESCRIPTION (provided by applicant): The Gordon Research Conference on Epithelial Differentiation and Keratinization has provided the premier forum for presentation and discussion of research in epithelial biology for several decades. This conference is routinely oversubscribed and is attended by the foremost international scientists in epithelial biology, as well as by more junior investigators, postdoctoral fellows, students, and scientists from industry. In recent years, the original focus on epidermal differentiation has broadened to encompass a wide range of topics of interest to epithelial biologists, including developmental biology of the skin and its appendages, stem cells and regenerative processes, epigenetics, the skin microbiome, immunology of the skin, and the role of the epidermal barrier in systemic disease. While the 2009 Conference highlighted hair follicle biology, the 2011 meeting will emphasize the epidermis, as well as covering a range of topics at the forefront of epithelial biology research. We will include scientists working in non-epidermal epithelia such as the retina, mammary epithelium, and intestine, and researchers whose interests lie outside epithelia, to provide additional insights, stimulate innovative approaches, and identify new areas of investigation. The program for 2011 provides a strong emphasis on epidermal barrier function and dysfunction; regulation and therapeutic applications of stem cells; inflammation; and morphogenesis. We will continue and build on our long-standing tradition of defining the most important problems and opportunities at the frontiers of epithelial biology, and facilitating interactions and discussion among scientists working in this area as well as leaders in other scientific areas. We aim to further the development of young investigators entering the field of epithelial biology, and to encourage the involvement of scientists from under-represented minorities. To accomplish these aims, the 2011 Conference will bring together an international cadre of participants including scientists from academia, industry, clinicians and basic researchers, young scientists and senior scientists, dermatologists and pathologists, and cell, developmental and molecular biologists in an atmosphere conducive to the free exchange of ideas. "Young Investigator Awards" will be given to the most promising graduate student and postdoctoral level presenters, and we will offer travel scholarships to outstanding minority applicants. The themes to be developed in the Main Sessions include: 1) Differentiation And Disease In Diverse Epithelia; 2) Epidermal Homeostasis and Barrier Function; 3) Therapeutic Applications Of Skin Cells; 4) the Role Of Immune System In Epithelial Biology and disease; 5) Skin Stem Cells; 6) Epithelial Morphogenesis; 6) Polarity, Adhesion, and the Cytoskeleton; and 7) Novel Regulatory Mechanisms. In addition, an oral Issues Rising session on Wednesday evening will highlight submitted abstracts to ensure that the program reflects exciting new topics that emerge between submission of this application and the meeting. The specific goal of this proposal is to generate funds to support Young Investigator Awards, and the travel, registration and for session chairs and invited speakers.