Eighth International Symposium on Tooth Enamel: Development, Properties and Patho

描述(申请人提供)：人牙釉质是体内矿化程度最高的组织，在严格的基因控制下发育形成结构精致的组织，具有独特的断裂和耐磨性能。有许多发育缺陷导致牙釉质发育异常，以及环境条件，如牙齿腐烂，可能破坏牙釉质导致牙齿脱落。我们对釉质发育和影响釉质发育的病理机制的了解有所增加，但仍然存在重大的知识差距。我们建议通过召集一组国际知名的新的研究人员来介绍和讨论有关牙釉质的最新信息，以帮助解决我们对牙釉质的发育和病理的理解中的这些不足。我们请求为第八届牙釉质的发育、特性和病理学国际研讨会提供支持。研讨会将于2011年6月12日至18日在芝加哥郊外的尤蒂卡伊利诺伊州饥饿岩石州立公园会议中心举行。本次研讨会将建立在1964年在伦敦举行的一系列非常成功的牙釉质国际研讨会的基础上，上一次是2005年在马萨诸塞州布鲁斯特举行的。具体地说，拟议的研讨会旨在1)批判性地解决自上次研讨会以来取得的许多重大进展；2)促进更好地了解牙釉质的发育和特性以及其在体内的破坏机制；3)激发新的想法，这些想法可能成为开发新的仿生方法的基础，用于修复和/或再生牙釉质，包括早期诊断和预防釉质龋病；4)鼓励包括少数群体、妇女和残疾人在内的新的研究人员参与这一日益增长的重要研究领域。拟议的研讨会最终将影响和帮助指导这些领域的研究活动，最终改善口腔健康。研讨会将限制为100人参加，以最大限度地发挥互动和关键讨论的作用。与之前的七次研讨会一样，会议记录(包括同行评议的文章和讨论)将在一份评级很高的科学期刊上发表。将涵盖的重要主题包括但不限于：成釉细胞生物学；釉质基质，无机相，釉质矿化；发育缺陷；进化和系统遗传学；生物仿生学/组织工程；通过非破坏性成像技术定量评估釉质矿物含量；以及早期龋病检测和釉质变化。鉴于自上一次牙釉质专题讨论会以来在这些领域取得的重大进展，拟议的专题讨论会是及时和具有高度针对性的。建议作出具体努力，促进纳入新的、少数群体和女性调查人员以及残疾人。 公共卫生相关性：拟议的研讨会将提供一个独特的论坛，专门介绍与牙釉质的发育和病理有关的新信息。研讨会的目标是增进我们对牙釉质的了解，并指导这一不断增长的领域的未来研究。考虑到人类牙釉质发育缺陷造成的巨大疾病负担，以及环境因素对这种特殊和独特的矿化组织的高度普遍的破坏(例如，龋齿、侵蚀)，所涵盖的材料具有临床意义。

DESCRIPTION (provided by applicant): Human tooth enamel is the most mineralized tissue in the body and develops under strict genetic control to form an exquisitely structured tissue that has unique fracture and wear resistant properties. There are numerous developmental defects that cause abnormal enamel development, as well as environmental conditions such as tooth decay that can destroy the enamel leading to tooth loss. Our understanding of enamel development and the pathologies that afflict it has grown, but significant knowledge gaps remain. We propose to help address these deficiencies in our understanding of the development and pathology of dental enamel by bringing together a group of internationally renowned and new investigators to present and discuss the latest information regarding dental enamel. We are requesting support for the Eighth International Symposium on the Development, Properties and Pathology of Tooth Enamel. The Symposium will be held June 12-18, 2011 at the Starved Rock State Park Conference Center in Utica Illinois outside of Chicago. This Symposium will build on a highly successful series of international symposia on tooth enamel that began in London in 1964 and was last held in Brewster Massachusetts in 2005. Specifically, the proposed Symposium is designed to 1) critically address the numerous significant advances that have taken place since the last symposium; 2) to promote a better understanding of the development and properties of tooth enamel and the mechanisms of its destruction in vivo; 3) to stimulate new ideas that can potentially serve as the basis for development of novel biomimetic approaches for the repair and/or regeneration of enamel including the early diagnosis and prevention of enamel caries; 4) to encourage the involvement of new investigators including minorities, women and person with disabilities in this growing area of important research. The proposed Symposium will ultimately influence and help direct research activities in these areas with the eventual outcome of improvement in oral health. The Symposium will be limited to 100 participants to maximize interactions and critical discussions. As with the seven previous symposia, the proceedings (including peer-reviewed articles and discussions) will be published in a highly rated scientific journal. Important topics to be covered include, but are not limited to; Ameloblast Cell Biology; Enamel Matrix, The Inorganic Phase, Enamel Mineralization; Defects of Development; Evolutionary and Phylogenetics; Biomimetics/Tissue Engineering; Quantitative Assessment of Enamel Mineral Content via Non-Destructive Imaging Techniques; and Early Caries Detection and Enamel Changes. Given the significant advances that have occurred since the last enamel Symposium in each of these areas, the proposed symposium is timely and highly topical. Specific efforts are proposed to promote inclusion of new, minority and female investigators as well as person with disabilities. PUBLIC HEALTH RELEVANCE: The proposed Symposium will provide a unique forum dedicated to the presentation of new information related to the development and pathology of dental enamel. The goal of the Symposium is to advance our knowledge of dental enamel, as well as to direct future research in this growing field. The material to be covered is clinically relevant given the tremendous disease burden caused by developmental defects of human dental enamel and the highly prevalent environmentally mediated destruction (e.g. dental caries, erosion) of this specialized and unique mineralized tissue.