GENETIC AND IMMUNOLOGICAL RISK FACTORS FOR AUTISM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该方案旨在提供临床数据和相关的生物样本，这将使基础广泛的努力，以确定遗传和免疫因素，导致自闭症和相关的神经发育障碍。具体目标1将解决自闭症受试者中发生从头遗传变化的假设，并且这些变化在允许的遗传背景中存在时可能是因果关系。具体目标2将解决这样的假设，即自闭症个体的母亲中循环的抗体可以在自闭症的发展中发挥作用，因为胎儿在子宫内发育期间暴露于这种抗体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is directed to providing the clinical data and associated biological samples which will enable a broad based effort to identify genetic and immunological factors that cause autism and related neurodevelopmental disorders. Specific aim 1 will address the hypothesis that de novo genetic changes occur in autistic subjects, and that these changes can be causative when present in a permissive genetic background. Specific aim 2 will address the hypothesis that antibodies circulating in the mothers of autistic individuals can play a role in the development of autism as a result of exposure of the fetus to such antibodies during intrauterine development.