COOPERATIVE LIFESTYLE INTERVENTION PROGRAM (CLIP)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 合作生活方式干预方案有两个目标。 第一，测试身体活动干预在治疗患有心血管疾病（CVD）或代谢综合征的老年人、超重和肥胖成人中对行动能力残疾的影响;第二（2）评估治疗超重/肥胖以及久坐行为对该人群行动能力残疾的额外益处。该试验的公共卫生相关性在于，干预措施将与服务不足的农村县的合作推广服务一起提供。该研究设计为一项三组随机对照试验，受试者为有活动障碍证据和有记录的CVD或代谢综合征证据的超重/肥胖老年人。这三种治疗包括：（1）健康教育控制条件，（2）身体活动的团体治疗计划，以及（3）旨在干预久坐行为和减肥的生活方式干预。该试验的主要目的是比较三个治疗组对18个月移动残疾变化的影响，如6分钟步行所定义的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are two goals of the Cooperative Lifestyle Intervention Program. First, to test the effect of a physical activity intervention in the treatment of older, overweight and obese adults who have cardiovascular disease (CVD) or the metabolic syndrome on mobility disability; and second(2) to evaluate the added benefit of treating overweight/obesity as well as sedentary behavior in this population on mobility disability. The public health relevance of the trial lies in the fact that the interventions will be delivered in conjunction with cooperative extension services in underserved rural counties. The study is designed as a three arm randomized controlled trial of older, overweight/obese adults who have evidence of mobility disability and either documented CVD or evidence of the metabolic syndrome. The three treatments will include: (1) health education control condition, (2) a group treatment program for physical activity, and (3) a lifestyle intervention that is designed to intervene on both sedentary behavior and weight loss. The primary aim of the trial is to compare the effects of the three treatment arms on 18-month change in mobility disability, as defined by the six-minute walk.