COOPERATIVE LIFESTYLE INTERVENTION PROGRAM (CLIP)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。合作生活方式干预计划有两个目标。首先，测试体力活动干预对患有心血管疾病(CVD)或代谢综合征的老年、超重和肥胖成年人行动能力障碍的治疗效果；以及(2)评估治疗超重/肥胖和久坐行为对行动能力障碍的额外益处。这项试验的公共卫生相关性在于，干预措施将与服务不足的农村县的合作推广服务一起提供。这项研究被设计为一项三臂随机对照试验，对象是年龄较大、超重/肥胖的成年人，他们有行动障碍的证据，并有记录的心血管疾病或代谢综合征的证据。这三种治疗将包括：(1)健康教育控制条件，(2)体力活动的集体治疗计划，以及(3)旨在干预久坐行为和减肥的生活方式干预。这项试验的主要目的是比较三种治疗武器对18个月活动障碍变化的影响，根据6分钟步行的定义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are two goals of the Cooperative Lifestyle Intervention Program. First, to test the effect of a physical activity intervention in the treatment of older, overweight and obese adults who have cardiovascular disease (CVD) or the metabolic syndrome on mobility disability; and second(2) to evaluate the added benefit of treating overweight/obesity as well as sedentary behavior in this population on mobility disability. The public health relevance of the trial lies in the fact that the interventions will be delivered in conjunction with cooperative extension services in underserved rural counties. The study is designed as a three arm randomized controlled trial of older, overweight/obese adults who have evidence of mobility disability and either documented CVD or evidence of the metabolic syndrome. The three treatments will include: (1) health education control condition, (2) a group treatment program for physical activity, and (3) a lifestyle intervention that is designed to intervene on both sedentary behavior and weight loss. The primary aim of the trial is to compare the effects of the three treatment arms on 18-month change in mobility disability, as defined by the six-minute walk.