METABOLIC EFFECTS OF ANDROGENICITY IN AGING MEN AND WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标 1)确定频繁采样的静脉葡萄糖耐量试验得出的胰岛素敏感性指数，与雌激素替代相比，是否会更高。 2)确定在解释中心性肥胖时，睾酮水平升高是否是老年男性胰岛素敏感性的重要预测指标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS 1) To determine whether the insulin sensitivity index derived from a frequently sampled intravenous glucose tolerance test will be greater with testosterone replacement compared to estrogen replacement. 2) To determine whether an increase in testosterone levels is a significant predictor of insulin sensitivity in older men when accounting for central adiposity.