OXPHOS upregulation to preserve vision in Leber's Hereditary Optic Neuropathy

利伯氏遗传性视神经病变（LHON）是一种毁灭性的致盲疾病，主要影响年轻男性。患者在十几岁或二十多岁之前视力正常，但随后视力迅速丧失，导致永久性失明。它是由我们从母亲那里遗传的线粒体DNA的基因变化引起的。线粒体是细胞的能量发生器。我们的目标是使用类似于女性激素的分子来提高能量，作为一种新的治疗方法，以保护高危LHON患者的视力。

Leber's Hereditary Optic Neuropathy (LHON) is a devastating blinding disease that preferentially affects young men. Sufferers have normal vision until teenage years or their twenties when a rapid loss of vision occurs that results in permanent blindness. It is caused by genetic changes in the mitochondrial DNA that we inherit from our mothers. The mitochondria are the cells' energy generators. We aim to use molecules similar to female hormones to boost energy as a new treatment to preserve vision in at-risk LHON individuals.