Boosting mitochondria- a new approach for protecting the aging optic nerve in glaucoma

增强线粒体——保护青光眼老化视神经的新方法

• 批准号: nhmrc : 1033506
• 负责人: A/Pr Ian Trounce
• 金额: $ 26.12万
• 依托单位: Centre for Eye Research Australia Ltd
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/boosting-mitochondria-new-nerve-glaucoma/110896
• 关键词: Boosting; mitochondria; new; approach; protecting

Increasing age is a major risk factor for neurodegeneration. We have recently shown that subjecting mice to intermittent periods of fasting improves mitochondrial function in the retina and reverses age-related decline in optic nerve vulnerability to injury. This project now aims to investigate key molecular pathway for restoring mitochondria and from this attempts to find more palatable therapeutic strategies for protecting the optic nerve from injury.

年龄增长是神经退行性变的主要危险因素。我们最近发现，间歇性禁食可以改善小鼠视网膜中的线粒体功能，并逆转与年龄相关的视神经损伤脆弱性下降。该项目现在旨在研究恢复线粒体的关键分子途径，并试图从中找到更好的治疗策略来保护视神经免受损伤。