Patient-Oriented Research in Skin Diseases

描述（由申请人提供）：本申请提议为加州大学弗朗西斯科分校（UCSF）皮肤病学教授Mary-Margaret Chren医学博士续签以患者为导向的研究中期职业研究者奖。Chren博士的长期职业目标是进行严格的研究，以改善皮肤病患者的健康，并利用她的研究来培养一流的研究人员，以患者为导向的皮肤病研究。这一新的奖项将建立在她以前的工作基础上，并实现她的近期职业目标：首先，扩大并完成下一阶段的非黑色素瘤皮肤癌（NMSC）队列研究，这是一项为期10年的NMSC治疗效果比较研究。（最常见的恶性肿瘤）;第二，以这些发现为基础，开发和执行针对NMSC治疗的多中心临床试验;第三，使用这些研究数据作为临床研究人员在以患者为导向的研究指导的基础;第四，通过在UCSF临床与转化科学研究所（CTSI）的导师发展计划中发挥更大的领导作用，增加她的指导活动范围。 拟议的研究将填补目前关于NMSC两种最常见治疗方法（手术切除和组织学引导的连续切除或Mohs手术）的比较疗效的知识空白。该研究将进行渐进式的发展步骤，设计和进行一项多中心随机对照试验，切除和莫氏手术治疗原发性面部基底细胞癌（BCC）。这些步骤包括建立研究，临床和利益相关者咨询小组，研究工具的组成，起草研究程序和程序的试点测试。在基础设施发展后，1200例原发性面部BCC患者将随机接受手术切除或莫氏手术。主要结局是5年时肿瘤复发;次要结局是皮肤相关生活质量。 拟议的指导计划有三个部分：教学课程，“动手”研究和职业发展;与更新的奖项，教学选项将完全整合与CTSI的高度指导课程的综合方案。Chren博士作为CTSI导师发展计划导师评估计划的领导者，将促进这种增强的整合。 研究计划和指导计划共同提供了一个新的五年战略，与NIH和NIAMS追求和应用知识以减少疾病负担的使命直接相关，并培训科学家进行此类研究。

DESCRIPTION (provided by applicant): This application proposes a renewal of a Midcareer Investigator Award in Patient-Oriented Research for Mary-Margaret Chren, MD, Professor of Dermatology at the University of California, San Francisco (UCSF). Dr. Chren's long-term career objectives are to perform rigorous research to improve the health of patients with skin diseases, and to use her research to develop first-rate investigators in patient-oriented research in skin diseases. This renewed award will build on her previous work and accomplish her immediate career objectives: first, to expand and complete the next phase of the Nonmelanoma Skin Cancer (NMSC) Cohort Study, a 10-year comparative effectiveness study of treatments for NMSC (the most common malignancy); second, to build on these findings to develop and perform a targeted multicenter clinical trial of treatments for NMSC; third, to use these research data as a substrate for the mentoring of clinician investigators in patient-oriented research; and fourth, to increase the scope of her mentoring activity by serving an expanded leadership role with the Mentorship Development Program of the UCSF Clinical & Translational Science Institute (CTSI). The proposed research will fill a gap in current knowledge about the comparative efficacy of the two most common treatments for NMSC, surgical excision and histologically-guided serial excision, or Mohs surgery. The research will undertake the incremental developmental steps to design and conduct a multicenter randomized controlled trial of excision and Mohs surgery for primary facial basal cell carcinomas (BCC). These steps include establishment of research, clinical, and stakeholder advisory groups, composition of study tools, drafting of study procedures, and pilot-testing of procedures. After infrastructure development, 1200 patients with primary facial BCC will be randomized to surgical excision or Mohs surgery. The primary outcome is tumor recurrence at five years; secondary outcome is skin-related quality of life. The proposed mentoring plan has three parts: didactic curricula, "hands-on" research, and career development; with the renewed award, didactic options will be fully integrated with CTSI's comprehensive program of highly-directed courses. This enhanced integration will be fostered by Dr. Chren's role as leader of the Mentor Evaluation Plan for the CTSI's Mentorship Development Program. Together, the Research Plan and Mentoring Plan provide a new five-year strategy that is directly relevant to the NIH and NIAMS missions of pursuing and applying knowledge to reduce disease burden, and training scientists to carry out such research.