A Multi-center Cohort Study of ACL Reconstruction Outcomes

候选人：沃伦·R。Dunn，医学博士，公共卫生硕士，范德比尔特大学骨科助理教授， 第二次被任命为中心医学与公共卫生系助理教授 健康服务研究他完成了美国矫形外科医师学会/矫形外科 研究和教育基金会特别医院卫生服务研究奖学金 运动医学与肩关节外科。在这个K23应用程序中，他提出了一个全面的 五年职业发展计划，包括临床流行病学的高级课程和培训， 生物统计学，临床试验设计，并进行指导研究项目调查后的结果 前交叉韧带（ACL）重建，以达到成为一个独立的目标， 外科医生科学家项目理念：身体活动和健身是健康人的重点领域之一 2010年，体育运动的参与度越来越高。与此雅阁的是，ACL损伤和随后的ACL损伤的数量 重建工作正在增加，估计每年的费用为20亿美元。现有证据表明， ACL重建术在术后2年成功恢复了术前功能，但这些研究 使用未经验证的结果指标，通常缺乏长期随访，并留下了风险因素， 预后差、移植物失败和额外的外科手术不明确。设计：多中心 涉及已建立的多中心骨科结局网络（MOON）的观察性队列研究 将被利用。建议的指导研究的目的是检验假设，客观 ACL重建时记录的预测因子与经验证的结果工具相关， 关节炎（目标1），以及额外的外科手术和移植失败（目标2）。范德比尔特是一位精力充沛的学者 环境能够提供必要的教育，培训和指导，使邓恩博士， 成为一名独立的以病人为导向的临床科学家。 前交叉韧带是人体内最常受伤的韧带，这一重要的稳定器的断裂会导致 导致膝盖进一步受伤的情况。ACL重建恢复了膝关节的稳定性， 然而，目前还不清楚手术是否能预防以后的膝关节炎。确定与质量相关的因素 关节炎是一个重要的公共卫生问题，尤其是在年轻人中。

Candidate: Warren R. Dunn, MD, MPH, Assistant Professor of Orthopaedics at Vanderbilt University with a secondary appointment as Assistant Professor in the Department of Medicine & Public Health at the Center for Health Services Research. He completed the American Academy of Orthopaedic Surgeons / Orthopaedic Research and Education Foundation Health Services Research Fellowship at the Hospital for Special Surgery on the Sports Medicine and Shoulder Service. In this K23 application he proposes a comprehensive five-year career development plan that includes advanced coursework and training in clinical epidemiology, biostatistics, clincal trial design, and to conduct a mentored research project investigating outcomes after anterior cruciate ligament (ACL) reconstruction in order to achieve the goal of becoming an independent surgeon scientist. Project Rationale: Physical activity and fitness is one of the focus areas of Healthy People 2010, and sports participation is increasing. In accord, the number of ACL injuries and subsequent ACL reconstructions is increasing at an estimated annual cost of 2 billion dollars. Available evidence shows that ACL reconstructions have been successful in restoring preoperative function at two years, but these studies have utilized non-validated outcome measures, often lack long-term follow-up, and have left risk factors for poor outcome, graft failure, and additional surgical procedures ill defined. Design: A multi-center observational cohort study involving an established Multi-center Orthopaedic Outcomes Network (MOON) will be utilized. The purpose of the proposed mentored research is to test the hypothesis that objective predictors recorded at the time of ACL reconstruction are associatedwith validated outcome instruments and arthritis (Aim 1), and additional surgical procedures and graft failure (Aim 2). Vanderbilt is a robust academic environment capable of providing the education, training, and mentorship necessary to enable Dr. Dunn to become an independent patient-oriented clinician scientist. The ACL is the most frequently injured ligament in the body, and disruption of this important stablizer leads to giving way episodes that cause further injury to the knee. ACL reconstruction restores stability to the knee, however, it is unclear if surgery prevents later arthritis of the knee. Identifying factors associated with quality of life and arthritis is critical because arthritis, particularly in young adults, is a major public health concern.