Development of a Miniature Plasma Brush for Dental Clinical Applications

描述(申请人提供)：该项目的主要目标是开发一种微型大气冷等离子体刷(m-ACPB)，用于牙科临床应用。该项目的创新之处在于利用新近发展的新型非热大气等离子体技术用于牙科治疗，以防止龋齿，提高牙科复合修复的耐久性和寿命。低温大气等离子体是一种具有化学反应的气体介质，能够穿透不规则的空洞和裂缝并杀灭细菌。此外，血浆物质可以扩散到液体中几毫米。这一特性使非热等离子体非常适合在潮湿的口腔环境中治疗、清洁、消毒龋齿和氟化牙釉质。牙齿腐烂或牙齿表面的等离子处理使我们能够避免污染，积极抗击细菌感染，有效地氟化牙齿表面，为龋齿物质提供额外的清洁，并通过简单的等离子处理工艺准备/设计牙齿表面，使其与粘合剂和密封剂材料牢固而持久地粘合。这种牙科临床应用将通过开发适合牙科临床使用的m-ACPB来实现。 公共卫生意义：Nanova，Inc.正在开发一种微型大气冷等离子刷子(m-ACPB)，用于牙科临床应用。该项目的创新之处在于利用最新研发的新型非热大气等离子体牙科治疗技术，预防龋齿，提高牙科复合修复体的耐久性和寿命，有望成为牙科领域的一项高影响力创新。

DESCRIPTION (provided by applicant): The main objective of this project is to develop a miniature atmospheric cold plasma brush (m- ACPB) for dental clinical applications. The innovation of this project is the utilization of the recently developed novel non-thermal atmospheric plasma technology for dental treatment to prevent tooth decay and improve the durability and longevity of dental composite restoration. Non-thermal atmospheric plasma is a gaseous medium that is chemically reactive and has the capability to penetrate irregular cavities and fissures and kill bacteria. Furthermore, plasma species can spread up to a few millimeters into a fluid. This feature make non-thermal plasmas extremely suitable to treat, clean, disinfect tooth decay, and fluorinate enamel in a wet oral environment. Plasma treatment of tooth decays or dental surfaces allows us to avoid contamination, actively fight bacterial infections, effectively fluorinate the tooth surfaces, offer additional cleaning to the decayed matters, and prepare/engineer the dental surface for strong and durable bonding to adhesive and sealant materials with a simple plasma treatment process. Such dental clinical applications will be achieved through the development of an m-ACPB that is suitable for dental clinical use. PUBLIC HEALTH RELEVANCE: Nanova, Inc. is developing a miniature atmospheric cold plasma brush (m-ACPB) for dental clinical applications. The innovation of this project is the utilization of the recently developed novel non-thermal atmospheric plasma technology for dental treatment to prevent tooth decay and improve the durability and longevity of dental composite restoration, and could become a high-impact innovation in dentistry.