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Malaria Drug Resistance and Disease Virulence

Malaria Drug Resistance and Disease Virulence
疟疾耐药性和疾病毒力
批准号:
8156841
负责人:
Thomas E Wellems
金额:
$87.48万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
我们的研究项目侧重于疟疾寄生虫如何对主要抗疟药物产生耐药性,以及为什么最致命的疟疾寄生虫(恶性疟原虫)对人类和某些其他灵长类动物的细胞表现出不同的感染性。在每一个领域,我们都在寻求研究进展,以提高对疟疾疾病过程的认识,从而支持开发或测试新的抗疟化疗、诊断工具和疫苗。我们计划的研究活动是多学科的,包括疟疾流行地区的实地研究以及基础实验室调查计划。
英文摘要
Our research project focuses on how malaria parasites become resistant to major antimalarial drugs and why strains of the most deadly malaria parasite (Plasmodium falciparum) show different infectivities to cells of humans and certain other primates. In each of these areas we seek research advances that can improve the knowledge of disease processes in malaria and thereby support the development or testing of new antimalarial chemotherapies, diagnostic tools, and vaccines. The research activities in our program are multidisciplinary and include field studies in malarious regions as well as programs of basic laboratory investigation.
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Malaria Drug Resistance and Disease Virulence
Biochemical And Biophysical Parasitology
Malaria Pathogenesis and Clinical Immunity
Dry Season Ecology of Malaria Vectors
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