Stochastic Simulation Of Excitation-contraction Coupling

完整3D模型的软件开发正在进行中。二维网格模型已被修订，以包括全细胞钙平衡的详细平衡。这个模型完全是用编译过的Java重新编码的，并且可以在本地集群的所有48个处理器上并行运行，效率高达70%。这使得探索参数和识别几种不同的新的传播机制成为可能，这些机制与窦房结细胞中SR钙释放的起搏功能有关。作为调节心率的关键参数的函数进行了广泛的模拟。该模型成功地解释了局部和全局钙释放的各种机制，以及这些机制之间的转换作为释放电流的函数。这些结果与自主神经系统如何调节心率的新模型一致。一本刊物目前正在接受杂志的评论。

SUMMARY OF WORK Software development on the full 3D model is proceding. The 2D grid model has been revised to include detailed balancing of whole-cell calcium balance. This model has been entirely recoded in compiled Java and spun out to run concurrently on all 48 processors of our local cluster with >70% efficiency. This has made it possible to explore parameters and identify several different new regimes of propagation relevant to the pacemaking function of SR calcium release in sin0-atrial node cells. Extensive simulations have been performed as a function of critical parameters regulating heart rate. The model successfully expalins the various regimes of localized and global calcium release and the transition among these regimes as a function of release current. These results are consistent with a new model of how heart rate is regulated by the autonomic nervous system. A publication is presently being reviewed by journal.