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Cytolytic T Cell Activity In Response To Primary RSV Infection In Mice

Cytolytic T Cell Activity In Response To Primary RSV Infection In Mice
小鼠原发性 RSV 感染的溶细胞 T 细胞活性
批准号：
8148428
负责人：
Barney Graham
金额：
$94.01万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8148428
关键词：
Cytotoxic T-LymphocytesInfectionMusresponse

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中文摘要
翻译
呼吸道合胞病毒（RSV）是婴幼儿下呼吸道感染的主要原因。RSV感染具有明显的免疫病理特征，这是由CD8+细胞毒性T淋巴细胞（CTL）介导的。过去的研究表明，ctl用于消除细胞的多种机制可能对病毒清除和rsv相关疾病有不同的影响。本研究旨在确定不同的CTL效应机制和CD25+ T调节细胞在清除原发性RSV感染中的作用，以及它们对病毒相关免疫病理的相对影响。
英文摘要
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and small children. RSV infection is characterized by significant immunopathology, which is mediated by CD8+ cytotoxic T lymphocytes (CTL). Past studies have suggested that the multiple mechanisms employed by CTLs to eliminate cells may have differential effects on viral clearance and RSV-associated illness. This study seeks to define the contributions of the different CTL effector mechanisms and CD25+ T regulatory cells to the clearance of primary RSV infection, as well as their relative impact on the virus-associated immunopathology.
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会议论文
Cellular Immune Responses to RSV infection in Mice
Rapid Development of Vaccines for Emerging Viruses
Factors Contributing To Immune-Enhanced Disease In The Pathogenesis of RSV
Vectors and Methods to Increase Immunogenicity during DNA Vaccination
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