Immunobiology of Myeloid and Lymphoid Cells

描述（由申请人提供）：我们建议提高达特茅斯医学院（DMS）免疫学培训项目的质量，该项目在过去的20年里一直得到T32资助，“骨髓和淋巴细胞的免疫生物学”。该计划的主要目标仍然是招募具有高度积极性和才华的博士后和研究生，并为他们提供一流的免疫学培训，为他们的科学研究事业做好准备，包括在学术界作为独立研究者的职业生涯。科学训练存在于动物和人类系统中；后者提高了我们吸引和培养博士/博士前博士和博士后学员的能力。该项目教师的研究兴趣跨越了广泛的免疫学领域，允许进入的学员在研究主题的概念和实验选择相当广泛。研究课题包括但不限于抗原提呈和免疫诱导、病毒免疫、肿瘤免疫和免疫治疗、炎症、疫苗、粘膜免疫、免疫调节和自身免疫。该提案的一个关键优势是来自DMS六个部门（生物化学、遗传学、医学、微生物学和免疫学、病理学、生理学和神经生物学）的19名资金充足的教员培训师的高质量研究项目。DMS拥有出色的研究设施，特别是2003年鲁宾大楼的扩建，该大楼是nci赞助的诺里斯棉花癌症中心。实验室设备齐全，可以支持免疫学、生物化学和分子生物学技术方面的全面研究。达特茅斯有AAALAC认可的动物设施。DMS对免疫学项目有大量的支持，基于项目教师的质量，NIH COBRE免疫学拨款和免疫治疗中心。免疫学培训包括几个研究生项目：分子和细胞生物学，实验和分子医学项目，以及医学博士/博士项目。与未来科学家的需求一致，达特茅斯的免疫学培训涉及一个高度互动的环境中培养的多/跨学科方法。学生和博士后受益于达特茅斯学院师生密切互动的传统特点，即教师的积极参与和科学交流。除了经典的科学培训，我们还开设了专业发展课程和研讨会，以帮助学生、博士后研究员和教师在他们的职业生涯中取得成功。免疫学项目有着出色的成功记录，我们建议在这一成功的基础上教育和促进下一代免疫学研究科学家。

DESCRIPTION (provided by applicant): We propose to improve the quality of the Immunology Training Program at Dartmouth Medical School (DMS) that has been supported by the T32 grant, "Immunobiology of myeloid and lymphoid cells", for the past twenty years. The primary goals of this program continue to be to recruit highly motivated and talented postdoctoral fellows and graduate students and to provide them with first-rate training in immunology to prepare them for scientific research careers, including careers in academia as independent investigators. Scientific training occurs in both animal and human systems; the latter enhances our ability to attract and train MD/PhD predoctoral and MD postdoctoral trainees. The program faculty's research interests span a wide range of immunologic areas that allows entering trainees a considerable breadth of conceptual and experimental choices of research topics. Research topics include, but are not limited to, antigen presentation and induction of immunity, immunity against viruses, tumor immunity and immunotherapy, inflammation, vaccines, mucosal immunity, regulation of immunity, and autoimmunity. A critical strength of the proposal is the high quality of the research programs of the nineteen well-funded faculty trainers, drawn from six DMS departments (Biochemistry, Genetics, Medicine, Microbiology & Immunology, Pathology, and Physiology and Neurobiology). DMS has outstanding research facilities, especially with the expansion of the Rubin building in 2003 that houses the NCI-sponsored Norris Cotton Cancer Center. The laboratories are fully equipped to support a full-range of state-of-the-art research in immunology, biochemistry, and molecular biology techniques. Dartmouth has AAALAC approved animal facilities. DMS has substantial support for the Immunology Program based on the quality of the program faculty, a NIH COBRE grant in immunology, and the Immunotherapy Center. Training in immunology spans several graduate programs: Molecular and Cell Biology, the Program in Experimental and Molecular Medicine, and the MD/PhD program. Consistent with the needs of future scientists, Immunology training at Dartmouth involves a multi/interdisciplinary approach nurtured by a highly interactive environment. Students and postdoctoral fellows benefit from a vigorous faculty involvement and scientific exchanges characteristic of the Dartmouth tradition of close student-faculty interactions. In addition to classic scientific training, we have created professional development courses and workshops to help students, postdoctoral fellows, and faculty succeed in their careers. The Immunology Program has an outstanding track-record of success and we propose to build on this success to educate and promote the next generation of research scientists in immunology.