Study the role(s) of p53 in embryonic stem cells
Study the role(s) of p53 in embryonic stem cells
批准号:
8157662
负责人:
Jing Huang
金额:
$39.77万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
在2009财政年度,我们使用ChIP-chip和基因表达微阵列方法来检查p53在胚胎干细胞中的作用。我们惊奇地发现p53在胚胎干细胞中调控Wnt信号通路。Wnt信号通路在肿瘤的发生发展中起着重要作用。其潜在机制目前正在实验室进行调查。在未来,我们计划使用体内小鼠模型来验证我们的假设,即p53在胚胎干细胞中具有双重功能。
英文摘要
During fiscal year of 2009, we used ChIP-chip and gene expression microarray approaches to examine the role of p53 in embryonic stem cells. We surprisingly found that p53 regulates the Wnt sginaling pathway in embryonic stem cells. The Wnt signaling pathway plays important role in development and tumorigenesis. The underlying mechanism is currently under investigation in the lab. In the future, we plan to use in vivo mouse model to test our hypothesis that p53 has dual functions in embryonic stem cells.
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会议论文
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Study the roles of p53 and p53 mutants in mesenchymal stem cells
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Study the role(s) of p53 in embryonic stem cells
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Study the role(s) of p53 in embryonic stem cells
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Stress responses in embryonic stem cellsvvvv
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Study the role(s) of p53 in embryonic stem cells
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Study the role(s) of p53 in embryonic stem cells
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海外基金