Socio-emotional dysfunction in schizophrenia and bipolar disorders: Facial, voca

社会情绪(SE)功能受损是精神分裂症(SZ)的一个显著特征，尤其是 从表情和韵律中感知情感。可想而知，这样的赤字导致融入社会的困难 从而在工作中保持友谊和关系。与其他精神疾病人群相比，如 双相情感障碍(BP)，SZ患者的SE功能受损更大，功能更差 结果比BP患者要高。因此，了解SE神经回路缺陷如何导致不同 相对于BP和健康对照组(HC)，SZ的社会和职业功能水平可以提供 开发针对不同精神病患者的具体培训计划和治疗方法的重要知识 人口。该项目将应用多模式神经成像-脑磁图(MEG)和弥散 张量成像(DTI)-评估SZ和BP患者SE功能改变的潜在机制。 脑磁图独特的时间和空间分辨率组合，与结构性磁共振成像(SMRI)相结合， 提供每毫秒发生的大脑过程的信息，并能够自上而下地评估 以及不同阶段自下而上的情绪加工。DTI补充了关于白人 在情绪处理的不同阶段，物质完整性会导致缺陷。要更好地了解SE如何 障碍在深圳社会功能中起中介作用，建议的研究将(1)评估SE神经网络 通过测量与SE处理相关的大脑活动和结构，SZ和BP独有并共享 通过脑磁图、核磁共振成像和DTI的使用；(2)通过以下方式评估深圳和BP的社会功能差异 评估感知情绪的能力和整合社会技能的能力，使用认知和 心理社会测量；以及(3)评估神经网络和相关解剖学和 在心理社会和社会功能测量方面的表现。总而言之，该项目的目标将提供一个 新的数据集，将阐明SZ、BP和HC中SE功能的共同和独特方面。

Impaired socio-emotional (SE) functioning is a prominent feature of schizophrenia (SZ), especially the ability to perceive emotion in faces and prosody. Conceivably, such deficits result in difficulties integrating into society and thus maintaining friendships and relationships at work. Compared to other psychiatric population such as bipolar disorder (BP), SZ patients experience greater impairments in SE functioning and poorer functional outcome than BP patients. Therefore, understanding how deficits in SE neurocircuitry contribute to different levels of social and occupational functioning in SZ relative to BP and healthy controls (HC) can provide important knowledge for developing specific training programs and treatments that target different psychiatric populations. This project will apply multimodal neuroimaging - Magnetoencephalography (MEG) and Diffusion Tensor Imaging (DTI) - to assess the underlying mechanisms of altered SE functioning in SZ and BP patients. MEG'S unique combination of temporal and spatial resolution, in combination with structural MRl (sMRI), provides information on brain processes occurring millisecond by millisecond and is able to evaluate top-down and bottom-up emotional processing at different stages. DTI adds complementary information about how white matter integrity contributes to deficits at different stages of emotion processing. To better understand how SE impairment mediates social functioning in SZ, the proposed research will (1) evaluate the SE neural networks unique to and shared in SZ and BP by measuring brain activity and structures associated with SE processing via the use of MEG, sMRI, and DTI; (2) evaluate the social functioning differences between SZ and BP by assessing the ability to perceive emotion and the ability to integrate social skills in society using cognitive and psychosocial measures; and (3) evaluate associations between neural networks and associated anatomy and performance on psychosocial and social functioning measures. Together, the aims of this project will provide a novel dataset that will elucidate the common and unique aspects of SE functioning in SZ, BP, and HC.