TAS::75 0849::TAS IN THIS PHASE I SBIR THE BREAST CANCER ADENOCARCINOMA CELL LI

生物能量功能障碍是大多数（<97%）转移性肿瘤的公认特征。在大多数肿瘤中突变的主要细胞增殖控制因子（例如p53、Ras、Myc、PI 3 K/Akt途径）的功能障碍导致线粒体氧化磷酸化（OXPHOS）的抑制和糖酵解的激活，称为瓦尔堡效应，其有助于对细胞凋亡的抗性。 Gencia开发了一种重组形式的人TFAM，即线粒体转录因子A（rhTFAM），经过修饰，使其能够穿过细胞屏障并特异性地导入线粒体。

Bioenergetic dysfunction is a well- recognized feature of most (<97%) metastasizing tumors. Dysfunction of major cell proliferation controllers mutated in the majority of neoplasms, such as the p53, Ras, Myc, PI3K/Akt pathways, results in suppression of mitochondrial oxidative phosphorylation (OXPHOS) and in activation of glycolysis, known as the Warburg effect, which contributes to the resistance to apoptosis. Gencia has developed a recombinant form of human TFAM, the mitochondrial transcription factor A (rhTFAM), modified to allow it to traverse cellular barriers and to be specifically imported into the mitochondria.