B Cell Epitope Discovery: Dengue, Hepatitis C, Ebola, and Chikungunya viruses

B细胞表位发现和抗体产生机制项目的目标是鉴定新的B细胞表位，阐明抗体介导的保护或发病机制的新机制，这些机制在人类对新发和再发感染性疾病和生物恐怖主义及其毒素的潜在因子的体液免疫中非常重要。该B细胞表位发现计划的结果将促进我们对抗体功能的理解，并极大地促进改进的免疫治疗剂、诊断剂和疫苗的设计和开发。此外，已知的B细胞表位和抗体功能的列表的扩展将促进更稳健的算法和数学模型的开发，以预测体内B细胞表位和抗体介导的对病原体和毒素的免疫应答。 该合同将确定登革热病毒、丙型肝炎病毒、埃博拉病毒和基孔肯雅病毒的B细胞表位。

The goal of the B Cell Epitope Discovery and Mechanisms of Antibody Production program is to identify novel B cell epitopes and elucidate novel mechanisms of antibody-mediated protection or pathogenesis that are important in humoral immunity in humans to emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. Results from this B cell epitope discovery program will advance our understanding of antibody functions and greatly facilitate the design and development of improved immunotherapeutics, diagnostics, and vaccines. In addition, an expansion of the list of known B cell epitopes and antibody functions will facilitate the development of more robust algorithms and mathematical models to predict B cell epitopes and antibody-mediated immune responses to pathogens and toxins in vivo. This contract will identify b cell epitopes for Dengue virus, Hepatitis C virus, Ebola virus, and Chikungunya virus.