Tissue Bank

组织库(核心C)提供基础设施，为进行翻译研究的研究人员提供来自骨髓增生性肿瘤(MPN)患者的标本，目的是为MPN患者开发创新疗法。组织库的功能是：1)获取MPN组织，2)作为MPN组织的储存库，3)分发MPN组织用于研究，4)通过将组织分发到核心实验室来促进生物标记物分析的性能。MPD研究联盟(MPD-RC)的成员和整个科学界都可以使用组织来进行翻译研究。核心C是一个重要的共享资源，它使转译研究能够改善MPN的诊断和分期，并最终导致分子靶向治疗的发展。组织库核心C的具体目标是：1)根据标准操作程序(SOP)，以高效、有组织的方式接收、处理、冷冻保存和存储MPD-RC临床现场确诊的MPN患者的组织。 2)为MPN组织提供一个中央储存库，这些组织与生物统计和数据管理核心B维护的基于网络的数据库中存储的基本数据相关联。这些基本数据包括临床、实验室和家族人口统计数据，使选择和分配最适合每个转译研究项目的组织成为可能。3)使冷冻后的组织随时可供MPD联盟调查人员和整个科学界进行研究。4)通过接收、处理、冷冻保存和存储MPN患者的组织，并将这些组织分发到联盟生物标记分析实验室，促进旨在预测疾病进展、血栓并发症和治疗反应的生物标记分析的执行。这些组织是在诊断时从患者身上收集的，并在项目6中描述的个别方案中指定的间隔。生物标记物分析提供了预期与临床试验终点相关的数据。来自600多名患者的标本目前存放在Core C中。来自275名患者的组织已分发给MPD-RC成员和广大科学界进行研究。

The Tissue Bank (Core C) provides the infrastructure to provide specimens from patients with myeloproliferative neoplasms (MPN) to investigators performing translational research for the purpose of developing innovative therapies for MPN pafients. The functions of the tissue bank are to: 1) acquire MPN tissues, 2) act as a repository for MPN tissues, 3) distribute MPN fissues for research, and 4) facilitate the performance of biomarker assays by distributing tissues to core laboratories. Tissues are available to members of the MPD Research Consortium (MPD-RC) and to the scientific community at large for the performance of translational research. Core C is an essential shared resource that enables translational research that will result in improved diagnosis and staging of MPN and ultimately lead to the development of molecularly targeted therapies. The specific aims of Tissue Bank Core C are to: 1) Receive, process, cryopreserve, and store tissues from MPN patients diagnosed at MPD-RC clinical sites in an efficient, organized manner according to standard operafing procedures (SOPs). 2) Provide a central repository for MPN tissues that are associated with basic data stored in the web-based data bank maintained by Biostatistics and Data Management Core B. These basic data include clinical, laboratory and familial demographic data that enable selection and distribution of tissues best suited for each translational research project. 3) Make the cryopreseved tissues readily available to the MPD Consortium investigators and scientific community at large for research studies. 4) Facilitate the performance of biomarker assays designed to predict disease progression, thrombofic complications, and therapeutic response, by receiving, processing, cryopreserving, and storing tissues from MPN patients, and distributing these tissues to consortium biomarker assay labs. These tissues are collected from patients at diagnosis and at intervals designated in individual protocols described in Project 6. Biomarker assays provide data that are anticipated to correlate with clinical trial endpoints. Specimens from more than 600 patients are cun-ently banked in Core C. Tissues from more than 275 patients have been distributed for research to members of the MPD-RC and the scientific community at large.