Imaging Core

成像核心将对小鼠肿瘤模型进行所有MR和生物发光成像研究， 项目1和2。此外，成像中心负责所有临床前和临床数据存档， 后处理和分析。核心人员将提供的服务包括：（a）界定和实施数据 采集/成像序列;（B）协助动物准备成像;（c）进行所有数据收集 9.4特斯拉MRI、7特斯拉MRI和Caliper生物发光成像系统;（d）初步数据 处理/图像重建和定量分析，包括PRM分析， （项目1和2）和临床成像数据（项目3）和成果数据;（e）原始数据的安全存档 （f）安排成像实验;及 (g)在成像实验的技术设计和实施方面为项目研究者提供支持。 这些服务的设计，部分是在“临床MRI服务”模式，因为连续，高容量的动物 扫描对于每个项目的成功至关重要，具体的动物MRI方案将因项目而异。 项目，但将主要包括系列研究，使用：标准T2加权; T1加权动态对比 增强;多层定量水扩散成像和动态对比增强渗透性 映射.核心还将有助于识别小鼠活检所需的空间坐标。 神经胶质瘤使用立体定位程序和facilite这一活动。核心小组还将协助移交管理代表 将数据发送至Imbio，LLC，对在多个研究中心采集的弥散和灌注MRI数据集进行场外分析。博士 Galban将担任核心B总监。Galban博士在小动物成像研究方面拥有丰富的经验 以及临床MRI数据的数字图像处理和分析。一名共同研究者和工作人员将提供协助 博士Galban与适应图像处理算法和相关分析软件，以确保 这项方案研究工作的需要得到充分满足。

The Imaging Core will perform all MR and bioluminescence imaging studies on mouse tumor models for Projects 1 and 2. In addition, the Imaging Core is responsible for all preclinical and clinical data archiving, post-processing and analysis. Core personnel will provide services including: (a) define and implement data acquisition/imaging sequences; (b) assist with animal preparation for imaging; (c) perform all data collection on the 9.4 Tesla MRI, 7 Tesla MRI and Caliper bioluminescence imaging systems; (d) preliminary data processing/image reconstruction and quantitative analysis including PRM analysis for both preclinical (Projects 1 and 2) and clinical imaging data (Project #3) and outcomes data; (e) secure archival of raw data and network transfer of reconstructed data from off-site facilities; (f) scheduling of imaging experiments; and (g) provide support to Program Investigators in technical design and implementation of imaging experiments. These services are designed, in part, after a "clinical MRI service" model since continual, high-volume animal scanning is essential for the success of each project Specific animal MRI protocols will vary with each project, but will primarily include serial studies using: standard T2-weighted; Tl-weighted dynamic contrast enhanced; multislice quantitative water diffusion mapping and dynamic contrast enhancing permeability mapping. The Core will also facilitate the identification of the spatial coordinates needed for biopsy of mouse gliomas using stereotaxic procedures and facilite this activity. The Core will also assist with transfer of MR data to Imbio, LLC for offsite analysis of diffusion and perfusion MRI data sets acquired at multiple sites. Dr. Galban will serve as Core B Director. Dr. Galban has extensive experience in small animal imaging research as well as digital image processing and analysis of clinical MRI data. A Co-investigator and staff will assist Dr. Galban with adapting image processing algorithm's and associated analysis software to ensure the needs of this programmatic research effort are fully met.