UT southwestern O'Brien Kidney Research Core Center

这是一份乔治M的更新申请。奥布莱恩肾脏研究核心中心， 位于达拉斯的德克萨斯西南医学中心。主任是彼得五十岚博士，教授内部 医学和儿科，以及德州大学西南部肾脏科主任。的总体目标 中心旨在促进基础科学家和临床研究人员之间的双向互动， 从根本上推进我们对肾脏发育和病理生理学的理解， 慢性肾脏病及其并发症的有效治疗。为实现这一目标，中心支持 生物医学研究核心，试点和可行性赠款，以及教育充实计划。四 生物医学研究核心是：1）动物模型，2）生理学，3）细胞生物学和成像，以及4）临床 &翻译研究。核心支持由UT的49名研究人员进行的肾脏研究 西南部，在北部和中部得克萨斯州的其他三个学术机构，以及一个外国机构， 正式隶属于德州大学西南分校研究领域是肾脏发育和 遗传学、肾生理学和病理生理学以及慢性肾病。此外，三个核心 提供服务或试剂，被位于许多大学的校外肾脏研究人员广泛使用。 美国和世界各地的机构。自2007年成立以来，该中心一直支持 111篇已发表的文章以及新的科学合作和资助申请。得到的研究能够 在该中心的支持下，为先天性心脏病的发病机制和治疗提供了新的见解。 肾脏异常，多囊肾，狼疮性肾炎，糖尿病肾病，电解质 以及慢性肾病的并发症。为了扩大肾脏研究人员的数量， 中心每年向新的研究者或已建立的研究者提供两笔试点和可行性赠款， 其他领域教育充实计划包括每月的研究研讨会，年度研讨会， 培训赠款，并通过该部提供的课程。临床科学以及实际操作 在每个核心中训练。

This is an application for renewal of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology at UT Southwestern. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will fundamentally advance our understanding of kidney development and pathophysiology and result in more effective treatments of chronic kidney disease and it complications. To achieve this goal, the Center supports Biomedical Research Cores, Pilot & Feasibility Grants, and an Educational Enrichment Program. The four Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology & Imaging, and 4) Clinical & Translational Research. The Cores support kidney research that is conducted by 49 investigators at UT Southwestern, three other academic institutions in North and Central Texas, and a foreign institution that is formally affiliated with UT Southwestern. Research is conducted in the areas of kidney development & genetics, renal physiology & pathophysiology, and chronic kidney disease. In addition, three of the Cores provide services or reagents that are widely utilized by off-campus kidney researchers located at numerous institutions throughout the U.S. and worldwide. Since its establishment in 2007, the Center has supported 111 published articles as well as new scientific collaborations and grant applications. Studies that are supported by the Center have provided new insights into the pathogenesis and treatment of congenital kidney abnormalities, polycystic kidney disease, lupus nephritis, diabetic nephropathy, electrolyte disturbances, and complications of chronic kidney disease. To expand the pool of kidney researchers, the Center awards two Pilot & Feasibility Grants per year to new investigators or established investigators from other fields. The Educational Enrichment Program includes a monthly research seminar, annual symposium, training grants, and courses offered through the Dept. of Clinical Sciences as well as practical hands-on training in each of the Cores.