Approaches for Synthesizing Data in Alcohol Research

 描述(由申请人提供)：这项提案的广泛目标是应用不同的方法将数据整合到酒精研究中。具体地说，元分析和综合数据分析(IDA)将被用来回答与评估家庭酗酒有关的不同研究问题。这一目标具有跨学科的影响，因为这些方法可以应用于酒精研究和其他领域的几乎任何主题。具体目标第一个项目是关于酗酒儿童的荟萃分析(MOCA)，包括综合文献，以进一步描述父母酗酒与子女冲动特征之间的关系，以及这种关系的调节因素。MOCA的目标是明确哪些与冲动有关的特征与拥有 父母酗酒的家族史。将被调查的主持人包括研究特征，如父母酗酒的可操作性(例如，儿童报告父母的酒精问题与评估父母的酒精问题)。这些目标将通过利用元分析多水平建模等先进技术来实现。第二个项目是对评估终生酒精使用障碍(IDA-LAUD)的研究进行综合数据分析，将包括将两个数据集与对终生酒精使用障碍(AUD)的多个评估相结合。这个项目的目标是在更具代表性的数据集上进一步表征与寿命AUD评估中的假阴性相关的可靠性问题。尽管假阴性是一种相对较低的碱基率现象，但其发生的后果是严重的。利用IDA是这一领域进一步研究的合乎逻辑的下一步。意义MOCA的结果将提供父母酗酒家族史和冲动之间关系的有价值的信息，这些信息可以用来为个性定制的干预计划提供信息。此外，IDA-LAOD的结果将提供有关终生AUD评估的局限性的有价值的信息，可用于改进评估该疾病和其他相关疾病的方法。

 DESCRIPTION (provided by applicant): The broad goal of this proposal is to apply different methods for integrating data to alcohol research. Specifically, meta-analysis and integrative data analysis (IDA) will be used to answer to different research questions relating to the assessment of familial of alcoholism. This objective has implications across disciplines given that these methods can be applied to almost any topic within alcohol research and other fields. Specific Aims The first project, a meta-analysis on children of alcoholics (MOCA), consists of synthesizing the literature to further characterize the relationship between parental alcoholism and traits related to impulsivity in offspring and moderators of this relationship. The goal of MOCA is to identify, specifically, which traits related to impulsivity are associated with having a family history of parental alcoholism. Moderators that will be investigated include study characteristics such as the operationalization of parental alcoholism (e.g., child report of parent's alcohol problems versus assessing parent for alcohol problems). These objectives will be met through the utilization of advanced techniques such as meta-analytic multilevel modeling. The second project, an integrative data analysis of studies assessing lifetime alcohol use disorder (IDA-LAUD), will consist of integrating two data sets with multiple assessments of lifetime alcohol use disorder (AUD). The goal of this project is to further characterize reliabilit problems relating to false negatives in the assessment of lifetime AUD in more representative data sets. Although false negatives are a relatively low base rate phenomenon, the ramifications of its occurrence are severe. Utilizing IDA is the logical next step for further research in this area. Significance The results from MOCA will provide valuable information on the relationship between having a family history of parental alcoholism and impulsivity, which could be used to inform personality- tailored intervention programs. Additionally, the results from IDA-LAUD will provide valuable information on limitations in the assessment of lifetime AUD, which can be used to improve methods for assessing this and other related disorders.