2016 Marine Natural Products Gordon Research Conference and Gordon Research Seminar

 描述（由申请人提供）：天然产物研究正在经历由基因组学驱动的第二个黄金时代，我们对天然产物生物合成的分子遗传学的理解，识别分子靶点和作用机制的化学生物学解决方案以及新的分析技术。特别是，来自海洋生物的天然产物提供了独特的分子支架，与细胞大分子和途径相互作用，以其他来源的分子所未见的方式改变表型和生理学。除了让科学家了解生物系统的功能外，天然产物作为对疾病相关靶点具有高度特异性亲和力的配体的作用为设计人类疾病（包括癌症、神经系统疾病和许多传染性病原体）的治疗方法提供了机会。通过这项提案，PI请求支持将于2016年3月5日至10日在加州文图拉举行的2016年海洋天然产品戈登研究研讨会（GRS）和戈登研究会议（GRC）。GRS是研究生和博士后展示和交流新数据和前沿思想的独特论坛，涵盖海洋天然产品领域与人类健康的应用。GRC将汇集来自学术界，工业界和政府（包括所有GRS参与者）的早期职业和成熟的研究人员，以解决海洋天然产品的发现和开发问题。报告和讨论将集中在天然产物如何调节细胞过程和提供治疗人类疾病的机会;天然产物研究在医学和海洋保护方面的应用;天然产物结构阐明、合成和作用模式确定方面的尖端技术;以及海洋天然产物的生物合成来源，包括基因组挖掘，异源表达，以及促进沉默基因簇表达的遗传学进步。研究生和博士后将在GRC之前的短格式GRS上获得海报和口头演讲的经验，从而通过与该领域的知名领导者互动，准备在GRC期间开发职业机会和新的合作。GRS和GRC的学院氛围将促进新的研究方向和早期职业科学家的培训机会，以及该领域领导者和新参与者之间的思想交流。国家卫生研究院的支持将针对研究生和博士后演讲者和讨论领导者在GRS和GRC的参与，以及女性和代表性不足的少数民族演讲者在GRC的参与。

 DESCRIPTION (provided by applicant): Natural products research is undergoing a second golden age driven by genomics, advances in our understanding of the molecular genetics of natural product biosynthesis, chemical biology solutions to identifying molecular targets and mechanism of action, and new analytical techniques. In particular, natural products from marine organisms have delivered unique molecular scaffolds that interact with cellular macromolecules and pathways, altering phenotype and physiology in ways not seen by molecules from other sources. In addition to informing scientists of how biological systems function, the role of natura products as ligands with highly specific affinities for disease-relevant targets has presented opportunities for designing therapies for human disease including cancer, neurological disorders, and many infectious pathogens. With this proposal the PIs request support for the 2016 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) to be held in Ventura, California on March 5-10, 2016. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and cutting edge ideas encompassing the field of marine natural products with applications to human health. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery and development of marine natural products. Presentations and discussion will focus on how natural products modulate cellular processes and present opportunities to treat human disease; applications of natural product research to medicine and marine conservation; cutting- edge techniques in natural product structure elucidation, synthesis, and determination of modes of action; and the biosynthetic origin of marine natural products including genome mining, heterologous expression, and genetic advances to facilitate the expression of silent gene clusters. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will facilitate new research directions and training opportunities for early career scientists, and the exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoc presenters and discussion leaders at the GRS and GRC, and female and under-represented minority presenters at the GRC.