An Administrative Core for the CaST Center

项目总结 行政核心将对中心的所有活动提供协调和监督。这会有帮助的 最大限度地提高互动和协同效应，实现对现有研究基础设施的最佳利用，例如 中心最先进的高性能计算环境，促进中心的参与 癌症系统生物学联盟(CSBC)活动的成员，确保来自 联合体的活动被适当地纳入中心的研究计划，并管理试点研究 将支持一年的中心内研究项目的基金，对整个中心研究做出贡献 主题。将建立一个有效的管理结构，以确保实现这些目标， 包括执行指导委员会(由中心主任、项目经理和NCI组成 项目官员)将确定中心项目的方向并提供全面指导；以及 项目经理，将经常与项目和核心领导会面，以确保计划的工作 按计划进行，操作问题得到迅速解决，软件、数据和 由项目活动产生的模型及时向公众发布，并与CSBC联系 根据需要建立数据协调中心。为进一步推进方案的整合和有效 为加强各成员之间的沟通，核心小组将每月举行会议，会议由两部分组成： (1)研究报告，将包括所有方案参与者；和(2)执行会议，将 仅限于执行指导委员会。后者将提供一个坦率地评估项目的论坛 资源和目标的进展和优先次序。它还将提供一个机会，探索可能的 与其他CSBC中心和NCI/NIH相关倡议的互动和合作。 行政核心的一项重要职能将是通过管理 数据和资源、财政审查和预算分析、编写进度报告以及遵守 监管要求。将任命一名合格的中心管理员协助中心主任和 项目经理负责执行这些任务。核心将负责组装世界级的 科学外部咨询委员会(EAC)向中心主任提供建议并提供公正的 对该中心研究计划的评估。核心将组织一次年度审查会议，会上 选管会成员将被要求就研究进展和未来方向提供反馈，并就以下问题提供建议 计划管理和试点项目进度的行政管理。核心还将负责 定义和跟踪广泛的量化评估指标集合，以评估 中心的产品。最后，行政核心将协调中心人员对所有人的参与 财团活动，包括参加会议和讲习班，为工作组和 技术委员会，并与美国国立卫生研究院的其他倡议对接。

PROJECT SUMMARY The Administrative Core will provide coordination and oversight across all Center activities. It will help maximize interactions and synergies, enable optimal use of available research infrastructure such as the Center's state-of-the-art High Performance Computing Environment, facilitate the participation of Center members to the activities of the Cancer Systems Biology Consortium (CSBC), ensure that input from Consortium activities is properly integrated into the Center's research program, and administer a pilot research fund which will support one-year intra-Center research projects contributing to the overall Center research theme. An effective management structure will be put in place to ensure that these objectives are achieved, including an Executive Steering Committee (comprising the Center's Directors, Project Manager, and NCI program officers) that will establish the direction of the Center's program and provide overall guidance; and a Project Manager who will meet frequently with project and core leads to ensure that planned work is proceeding according to schedule, that operational problems are quickly resolved, and that software, data, and models generated by project activities are released to the public in a timely manner, liaising with the CSBC Data Coordination Center as needed. To further promote integration of the program and effective communication among its various members, the Core will organize monthly meetings comprised of two parts: (i) research presentations, which will include all program participants, and (ii) executive meetings, which will be limited to the Executive Steering Committee. The latter will provide a forum for candid assessment of project progress and prioritization of resources and objectives. It will also offer an opportunity to explore possible interactions and collaborations with other CSBC Centers and related NCI/NIH initiatives. An important function of the Administrative Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and compliance with regulatory requirements. A qualified Center Administrator will be appointed to assist the Center's Directors and Project Manager with the execution of these tasks. The Core will be responsible for assembling a world class scientific External Advisory Committee (EAC) to advise the Center's Directors and to provide an impartial assessment of the Center's research program. The Core will organize an annual review meeting where the EAC members will be asked to offer feedback on research progress and future directions, as well as advice on program management and the administration of the pilot project progam. The Core will also be responsible for defining and tracking a broad collection of quantitative evaluation metrics to assess the quality and utility of the Center's products. Finally, the Administrative Core will coordinate the participation of Center personnel to all Consortium activities, including attending meetings and workshops, contributing to working groups and technical committees, and interfacing with other NIH initiatives.