Retinal eye-tracking as a diagnostic tool for traumatic brain injury and concussion.

 描述（由申请人提供）：我们项目的目标是进一步开发跟踪扫描激光检眼镜（TSLO），以便广泛使用该技术，为患有运动相关头部损伤（如创伤性脑损伤和脑震荡）的NCAA学生运动员进行高分辨率眼动跟踪。跟踪是通过一个基于图像的软件程序来完成的，该软件程序监视视网膜随时间的图像，同时记录眼睛的位移。目前，该系统是标准眼科仪器中使用的最准确、最快速和最实用的眼睛跟踪系统。TSLO能够以960 Hz的频率非侵入性地跟踪视网膜，精度为0.2弧分或~1微米。这种精确度在临床上是前所未有的，在撞击后和脑震荡后恢复期间立即监测眼球运动的微小变化时至关重要。目前的瞳孔眼动跟踪技术缺乏准确测量注视眼动（FEM）所需的灵敏度，这是许多神经系统疾病的早期指标，研究级眼动跟踪系统要么侵入性太强，要么成本太高，无法作为诊断工具实施。TSLO作为一种脑震荡筛查工具将是运动医学诊所和更衣室的完美选择。因此，有一个重大的科学和商业机会， 提高和扩大TSLO的技术能力。

 DESCRIPTION (provided by applicant): The goal of our project is to further develop the tracking scanning laser ophthalmoscope (TSLO) to enable widespread use of the technology for high-resolution eye-tracking for NCAA student-athletes with sports related head injuries, such as traumatic brain injury and concussions. Tracking is done via an image-based software program that monitors the image of the retina over time while simultaneously logging the displacements of the eye. Currently, this system is the most accurate, fast and functional eye-tracking system used in a standard ophthalmic instrument. The TSLO has the ability to non-invasively track the retina at 960 Hz, with an accuracy of 0.2 arcminutes or ~1 micron. This level of accuracy is unprecedented in the clinic and is crucial when monitoring minute changes in eye motion immediately after the time of impact and during post-concussion recovery. Current pupil eye-tracking technologies lack the sensitivity needed to accurately measure fixational eye movements (FEMs), an early stage indicator of many neurological disorders, with research grade eye-tracking systems being either far too invasive or costly to implement as diagnostic tools. The TSLO as a concussive screening tool would be the perfect fit for Sport Medicine Clinics and the locker room. Thus, there is a significant scientific and commercial opportunity for the improvement and expansion of the technical capabilities of the TSLO.