Cell Volume Regulation; Implications for Hydration and Nutrition in Health and Disease

 描述（由申请人提供）：生物体需要吸收能量和构建模块，并消除废物。因此，将它们与环境隔开的屏障不能完全密封水，离子和小有机分子的运动。因此，细胞从一开始就建立了基本的机制来维持和调节其水含量和体积。当这些基本功能被破坏时，可能会对生物体产生严重后果，并且盐和水运输疾病涉及影响超过50%人口的急性和慢性疾病，并且已经记录了每年花费数十亿美元的医疗保健系统。第11届细胞体积调节国际研讨会（Cell Biology of Volume Regulation and Fluid Homeostasis）的目标是涵盖细胞体积调节的基本机制及其在几种主要疾病中的意义，包括高血压，脑疾病和肺和肾脏疾病。具体来说，我们提出了10个科学会议：会议的第一部分细胞生物学的体积调节和流体稳态，分为5个会议：I.1细胞体积调节的分子机制：转运蛋白和离子通道; I.2盐敏感机制的调节细胞凋亡和自噬; I.3细胞体积调节细胞增殖和迁移; I.4细胞体积调节细胞增殖和迁移; I.5细胞体积调节细胞增殖和迁移。I.4渗透和机械敏感离子转运机制的脂质调节;和I.5水合作用和水通过膜的转运。会议的第二部分容量调节和液体稳态疾病，分为4个部分：II.1盐转运在高血压中的作用; II.2液体电解质对多囊肾疾病进展的贡献; II.3囊性纤维化的渗透调节和水合作用;和II.4神经和脑疾病的渗透调节。第十届科学会议将专门讨论青年研究人员。此外，我们提出了一个新的教育推广倡议，将包括高中和社区大学的学生。这将通过“与教授共进午餐和学习”会议来实现，该会议将侧重于饮食中的盐和水以及关于科学和科学家个人经验的小组讨论。这是过去十年来第一次在美国组织细胞体积调节国际研讨会，我们认为这对促进美国科学家与国际社会的互动和促进这一领域的国际合作至关重要。 叙述：这次关于“细胞体积调节和流体稳态”的国际科学会议的主要目标是涵盖细胞体积调节的基本机制以及这些机制在几种主要疾病中的作用，包括高血压，脑疾病和肺和肾脏疾病。此外，会议将包括一个教育推广计划，将包括高中学生和社区大学的学生，以培养学生对科学的兴趣。

 DESCRIPTION (provided by applicant): Living organisms necessitate the uptake of energy and of building blocks, and the elimination of waste. Therefore, the barrier that separates them from the environment cannot be completely tight to the movement of water, ions, and small organic molecules. As a consequence, cells from their beginning created basic mechanisms to maintain and regulate their water content and volume. When disrupted, these basic functions can have severe consequences for an organism, and diseases of salt and water transport are involved in both acute and chronic conditions that impact over 50% of the population, and have been documented to cost the health care system billions of dollars annually. The goal of the proposed symposium Cell Biology of Volume Regulation and Fluid Homeostasis, an 11th International Symposium on Cell Volume Regulation is to cover both the basic mechanisms of cell volume regulation and their implications in several major diseases including hypertension, brain disorders and lung and kidney diseases. Specifically, we propose 10 scientific sessions: The first part of the conference Cell Biology of Volume Regulation and Fluid Homeostasis, is divided into 5 sessions: I.1 Molecular Mechanisms of Cell Volume Regulation: Transporters and Ion Channels; I.2 Salt-sensitive Mechanisms in Regulation of Apoptosis and Autophagy; I.3 Cell Volume Regulation in Cell Proliferation and Migration; I.4 Lipid Regulation of Osmotic- and Mechano-sensitive Ion Transport Mechanisms; and I.5 Hydration and water transport through the membrane. The second part of the conference Diseases of Volume Regulation and Fluid Homeostasis, is divided into 4 sessions: II.1 Role of Salt Transport in Hypertension; II.2 Fluid-Electrolyte Contributions to Disease Progression in Polycystic Kidney Disease; II.3 Osmoregulation and Hydration in Cystic Fibrosis; and II.4 Osmoregulation in Neurological and Brain Disorders. A 10th scientific session will be dedicated to Young Investigators. In addition, we propose a new educational outreach initiative that will include high school and community college students. This will be achieved via a "Lunch and Learn with a Professor" sessions that will focus on salt and water in the diet and on small groups discussions about science and scientists personal experiences. It is the first time in the last decade that an International Symposium on Cell Volume Regulation is organized in the United States, which we believe is critically important to facilitate the interaction of the American scientists to the international community and foster international collaborations in this area. Narrative: The major goal of this international scientific meeting on "Cell Volume Regulation and Fluid Homeostasis" is to cover both the basic mechanisms of cell volume regulation and the roles of these mechanisms in several major diseases including hypertension, brain disorders and lung and kidney diseases. In addition, the meeting will include an educational outreach program that will include high school students and community college students to foster the interest of the students to science.