Point-of-Care Rapid RNA Diagnosis of Influenza Virus

 描述(申请人提供)：流感以季节性流行病的形式在世界各地迅速传播，并以医院和其他卫生保健费用和生产力损失的形式强加了相当大的经济负担[1，2]。在病毒扩散到人类种群之前，及早预测、检测、表征动物宿主中的病毒并进行风险评估，对于保护公众健康至关重要[3，4]。现有的或新出现的传染病造成的全球负担强调了护理点(POC)诊断的必要性，以加强及时的识别和干预[5]。为了更好地为下一次大流行做准备，我们需要开发简单易用的测试，以确定新出现的流感病毒的特征和需求，以低成本利用多路平台提供护理点流感诊断设备[5]。一个高度敏感的， 将开发在护理地点检测流感病毒的简单纸条分子测试。

 DESCRIPTION (provided by applicant): Influenza rapidly spreads around the world in seasonal epidemics and imposes a considerable economic burden in the form of hospital and other health care costs and lost productivity [1, 2]. Early prediction, detection, characterization and risk assessment of viruses in their animal hosts, before they spread into the human population, are critical to protect public health [3, 4]. Global burdens from existing or emerging infectious diseases emphasize the need for a point-of-care (POC) diagnostics to enhance timely recognition and intervention [5]. To better prepare for the next pandemic, we need to develop simple and easy-to-use tests for characterizing newly emerging influenza viruses and needs of point of care flu diagnostic devices at low cost with a multiplex platform [5]. A highly sensitive, simple paper strip molecular test that detects the Influenza virus at the point-of-care will be developed.