Pathologies of action control: Amygdala-striatal interactions and the development of habits.

基底神经节功能的改变，无论是由神经退行性疾病、中风、损伤还是疾病引起的，都可产生动作控制的病理改变。这一建议将评估杏仁核事件对基底神经节结构的作用，尤其是背纹状体，在这一过程中。通过动物模型，我们将比较中央杏仁核和基底外侧杏仁核对纹状体的输入在决策、选择和行为向反射性、习惯性反应的转变中的作用。

Changes in basal ganglia function, whether produced by neurodegenerative disorders, stroke, injury or disease, can produce pathological changes in action control. This proposal will assess the role of amygdala afferents on basal ganglia structures, most notably the dorsal striatum, in this process. Using an animal model we will compare the role of central and basolateral amygdala inputs to striatum in decision-making, choice and the transition of actions to reflexive, habitual responses.