Cell Identity and Signaling Research Program (Project-001)

细胞识别和信号研究计划 项目摘要 自上次竞争性更新以来，长期存在的细胞生长和分化计划， 自1993年成立以来，它被重组为细胞识别和信号（CIS）计划。响应于 在2009年CCSG审查中表达的担忧，细胞生长和分化计划领导人，高级 领导层和执行委员会与外部审计委员会一起进行了全面的方案审查， 咨询委员会。达成了一项共识，重新组织该方案，以解决审查关切， 加强协作互动。重新组织和重新定位的CIS计划需要新的教师 招聘，以加强重组计划和普渡大学癌症中心的使命 研究（PCCR）。重组后的CIS方案将PCCR作为基本 癌症细胞生物学的新发现要做到这一点，CIS利用普渡大学的基础优势， 生物科学、药物化学、药学、兽医学和营养科学，以解决 癌细胞生物学的关键课题。具体而言，独联体方案的总体使命是调查关键问题， 影响信号通路和基因表达程序的分子，并了解细胞如何 身份被确定或改变。独联体成员国致力于了解维持 细胞身份和纠正癌细胞经历的身份危机。独联体成员国代表7个 不同的普渡大学学术部门和5个学院，并已从26名成员增长到33名成员 自上次CCSG审查以来增加了14个新成员。CIS计划目前 约430万美元（直接成本）的NCI和其他同行评审的癌症相关支持组合。的结果 PCCR支持和CIS计划领导人发起的计划变更，CIS合作 出版物大幅增加，计划内出版物占8%（增长约38%）， 方案间合作占25%（增长约68%）;机构间合作占17%， 强大的合作出版率约为43%。CIS计划的结构是为了解决蜂窝问题， 通过专注于两个主要的研究集群：信号传导和细胞生长控制和调节， 基因表达。CIS计划的成员也有一个共同的目标，即专注于基础科学， 并表征细胞过程中的关键分子，这些分子可以转化为癌症解决方案。的 独联体成员国研究的生物学专业知识和癌症靶点使他们能够在独联体内部开展合作， CIS计划和其他PCCR研究计划的成员之间，增加了相当大的价值， PCCR。

Cell Identity and Signaling Research Program Project Summary Since the last competitive renewal, the long standing Cell Growth and Differentiation Program, which had been in existence since 1993, was reorganized to the Cell Identity and Signaling (CIS) Program. In response to concerns expressed in the 2009 CCSG review, the Cell Growth and Differentiation Program Leaders, Senior Leadership, and Executive Committee conducted a full programmatic review in conjunction with the External Advisory Committee. A consensus was reached to reorganize the Program to address review concerns and enhance collaborative interactions. The reorganized and refocused CIS Program required new faculty recruitment to strengthen the reorganized Program and the mission of the Purdue University Center for Cancer Research (PCCR). The reorganized CIS Program serves the PCCR as the central component for basic discovery in cancer cell biology. To do this, CIS leverages Purdue University foundational strengths in the biological sciences, medicinal chemistry, pharmacy, veterinary medicine, and nutrition science, to address critical topics in cancer cell biology. Specifically, the overall mission of the CIS Program is to investigate key molecules that impact signaling pathways and gene expression programs, and to understand how cellular identity is determined or altered. CIS members are committed to understanding what is needed to maintain cellular identity and correcting the identity crisis that cancer cells undergo. The CIS membership represents 7 different Purdue academic departments and 5 colleges, and has grown from 26 members to 33 members through the addition of 14 new members since the previous CCSG review. The CIS Program has a current portfolio of ~$4.3 million (direct costs) of NCI and other peer-reviewed, cancer-related support. As a result of PCCR support and the programmatic changes initiated by the CIS Program Leaders, CIS collaborative publications have dramatically increased with intra-programmatic publications at 8% (~38% increase) and inter-programmatic at 25% (~68% increase); inter-institutional collaborations are at 17%, providing an overall strong collaborative publication rate of ~43%. The CIS Program is structured to address the issue of cellular identity by focusing on two major Research Clusters: Signaling and Cellular Growth Control and Regulation of Gene Expression. CIS Program members also share the common goal of focusing on basic science to identify and characterize key molecules for cellular processes that can be translated into cancer solutions. The biological expertise and cancer targets that CIS members study allow them to develop collaborations within the CIS Program and among members of the other PCCR Research Programs, adding considerable value to the PCCR.