Pharmacological preconditioning and sodium/hydrogen exchange inhibition to optimise preservation of the donor pig heart

心脏移植已被证实是治疗终末期心力衰竭患者的一种非常有益的治疗方法，但其成功受到供者心脏供应有限的限制。许多可以考虑用于心脏移植的心脏不能使用，因为潜在的捐赠者心脏在捐赠者去世后可能会受到损害。造成这种损害的部分原因是死后心脏功能的恶化，部分原因是心脏移植前的取出和冷藏过程。这项研究将研究两种优化供体心脏质量和保存以供移植的新方法。这项研究中要研究的治疗方法旨在防止在死后和移植过程中对供者心脏的损害。这些研究将在我们实验室开发的猪心脏移植模型中进行。这些治疗将在脑死亡诱导后对供体猪进行，在心脏移植期间也将对受者进行。由于该模型非常接近于人类心脏移植的方方面面，这些研究得出的任何积极发现都将直接适用于人类移植。改进供体心脏的保存将使手术更安全，并有可能增加可用于移植的心脏数量。由于许多捐赠者提供多种器官进行移植，例如肾、肝、肺和胰腺，我们正在研究的治疗方法有可能改善所有这些器官在移植后的恢复。

Heart transplantation has become established as an extremely beneficial treatment for patients with end-stage heart failure, however its success is limited by the restricted availability of donor hearts. Many hearts that could be considered for heart transplantation cannot be used because of damage that can occur to potential donor hearts after the death of the donor. This damage is caused in part by deterioration in heart function after death and in part by the process of removal and cold storage that occur prior to transplantation of the heart. This study will examine two new methods of optimising the quality and preservation of the donor heart for transplantation. The treatments to be investigated in this study are aimed at preventing damage to the donor heart after death and during the process of transplantation. The studies will be conducted in a pig model of heart transplantation that we have developed in our laboratory. The treatments will be administered to the donor pig after induction of brain death and also to the recipient during transplantation of the heart. As the model closely mimics all aspects of human heart transplantation, any positive findings that stem from these studies will be directly applicable to human transplantation. Improved preservation of the donor heart will make the operation safer and will potentially increase the number of hearts that can be used for transplantation. As many donors provide multiple organs for transplantation eg kidneys, liver, lungs and pancreas, the treatments that we are investigating have the potential to improve the recovery of all these organs after transplantation.