Plasma Exchange and Glucocorticoids in ANCA Associated Vasculitis: A Randomised Controlled Trial (PEXIVAS Australia)

血管炎是一种危及生命的疾病，目前对这种疾病的治疗并不令人满意。本临床试验旨在确定1）血浆置换是否可以降低死亡率和由于这种疾病导致的严重肾衰竭的发展，以及2）使用较低剂量的皮质类固醇是否可以减少治疗的感染并发症。这项试验是一项重大国际努力的一部分，将涉及来自澳大利亚、英国、欧洲、美国和新西兰的共计500名患者。

Vasculitis is a life-threatening disease, and the current treatment for this condition is not satisfactory. This clinical trial aims to determine 1) if plasma exchange can lower mortality and the development of severe kidney failure due to this disease, and 2) if the use of lower doses of corticosteroids can lessen the infectious complications of treatment. This trial is part of a major international effort which will involve a total of 500 patients from Australia, UK, Europe, USA and NZ.