Precision Prevention of Colorectal Cancer: understanding tumourigenesis in high risk people to optimise prevention

肠癌是澳大利亚第二大常见的癌症死亡原因，也是最容易预防的癌症之一。我们知道有些人患癌症的风险很高，因为他们的DNA发生了变化，或者他们有很多癌前病变（息肉）。肠癌在50岁之前的年轻人中呈上升趋势，原因不明。如果我们能确定哪些人有高风险，并了解澳大利亚年轻人患癌的方式和原因，我们就能预防这些癌症。

Bowel cancer, Australia’s second most common cause of cancer death, is one of the most preventable cancers. We know some people have a high risk because they carry changes in their DNA, or they have many pre-cancerous growths (polyps). Bowel cancer is increasing in young people, before 50 years of age, with no known reason. If we can identify people who have a high risk and understand how and why it develops in young Australians, we can prevent these cancers.