Preclinical development of TLR signalling inhibitors for prevention of preterm labour and fetal inflammatory injury

早产影响到8%的澳大利亚新生儿，是婴儿和儿童健康问题的主要原因。预防或延迟早产的治疗是迫切需要的。这项研究将研究抑制早产诱因的新药。我们将评估药物在小鼠和人类胎盘组织中的作用，以证明早产时发生的炎症损伤的安全性和胎儿保护作用。这项研究的成功完成有望在女性中进行临床试验。

Preterm birth affects 8% of Australian births and is a major cause of infant and child health problems. Therapies to prevent or delay prematurity are urgently required. This study will investigate new drugs that suppress the triggers of preterm labour. We will evaluate drug effects in mice and human placental tissue, to demonstrate safety and fetal protection from inflammatory injury that occurs with prematurity. Successful completion of the study is expected to lead to clinical trials in women.