Preventing myocardial infarction: A mouse model of atherosclerotic plaque instability/rupture as unique tool for establishing novel pharmacological strategies and targeted molecular imaging

心肌梗塞在没有征兆的情况下发作，从而导致死亡或严重残疾。它通常是由动脉粥样硬化斑块突然破裂和冠状动脉闭塞引起的。由于缺乏斑块破裂的动物模型，这方面的研究受到了阻碍。我们新建立了一个小鼠模型，现在我们将使用它来生成新的工具来成像和识别容易破裂的斑块，并开发预防斑块破裂和心肌梗死的新疗法。

Myocardial infarction strikes without warning and thereby causes death or major disability. It is typically caused by sudden rupture of atherosclerotic plaques and occlusion of coronary arteries. Research on this was hampered by the lack of an animal model of plaque rupture. We have newly established a mouse model, which we will now use to generate novel tools to image and identify plaques that are prone to rupture and to develop novel therapies preventing plaque rupture and myocardial infarction.