Prevention of HIV-1 infection by adeno associated virus vector-delivered broadly neutralizing antibodies or antibody-like molecules

一种有希望的中和分子增加了艾滋病毒疫苗的希望。目前尚不清楚这种分子在反映“真实世界”暴露的条件下预防艾滋病毒感染的效果如何，包括以携带病毒的细胞或在精液存在的情况下自由漂浮的病毒的形式暴露于艾滋病毒。我们将评估这种分子在这些条件下抑制艾滋病毒样病毒传播的能力。这些实验将确定预防艾滋病毒感染的要求。

A promising neutralizing molecule has boosted hopes of an HIV vaccine. It remains unknown how well this molecule prevents HIV infection under conditions reflecting “real world” exposure, including exposure to HIV in the form of cells carrying virus or free-floating virus in the presence of semen. We will assess this molecule for their ability to inhibit transmission of HIV-like viruses under these conditions. These experiments will define requirements to protect against HIV infection.