Profiling circulating DNA and RNA to identify mechanisms of therapeutic resistance and response in metastatic castration-resistant prostate cancer

苯扎鲁胺是一种有效的激素疗法，可以提高晚期前列腺癌患者的存活率。不幸的是，所有前列腺癌最终都会对苯扎鲁胺产生抗药性，并不是所有的男性最初对治疗都有反应。我将寻找血液标志物，预测哪些男性从苯扎鲁胺治疗中受益，并试图了解对苯扎鲁胺的耐药性是如何发生的。这可能导致更有效地使用苯扎鲁胺，从而在晚期前列腺癌中获得更好的结果。

Enzalutamide is a powerful hormone treatment that improves survival for men with advanced prostate cancer. Unfortunately, all prostate cancers eventually become resistant to enzalutamide and not all men initially respond to treatment. I will look for blood markers that predict which men benefit from enzalutamide treatment and try to understand how resistance to enzalutamide occurs. This may lead to more effective use of enzalutamide resulting in better outcomes in advanced prostate cancer.