Prospective Imaging Study of Ageing: Genes, Brain & Behaviour

虽然在澳大利亚，痴呆症的负担发生在晚年，但潜在的脑部疾病在痴呆症发作之前积累了几十年。如果在这一关键时期，即在明显的认知能力下降开始之前，引入疾病改良干预措施，则最有可能避免以后的疾病负担。因此，为了减轻澳大利亚未来的痴呆症负担，当务之急是在他们还相对年轻的时候就识别出那些有痴呆症风险的澳大利亚人。

While the burden of dementia in Australia occurs late in life, the underlying brain disease accumulates for decades prior to dementia onset. Disease modifying interventions have the greatest potential to avert later disease burden if introduced during this crucial window, well before the onset of clear cognitive decline. To reduce Australia's future dementia burden, it is thus imperative to identify those Australians at risk of dementia whilst they are still relatively young.