Protecting the efficacy of antimalarial therapies with novel approaches to suppress the emergence of drug resistance

对抗疟药物具有抗药性的恶性疟原虫寄生虫的不断出现和传播，严重威胁着全球消灭疟疾运动。然而，在获得对一种药物的耐药性时，寄生虫可能变得对其他抗疟药物更敏感。该项目旨在1）测试具有相反选择力的药物对在体外抑制耐药性的能力，2）定义这些相反进化力的生理和分子基础。

The global campaign to eliminate malaria is under serious threat from the continuing emergence and spread of Plasmodium falciparum parasites resistant to antimalarial drugs. However in acquiring resistance to one drug, the parasite can become more susceptible to other antimalarials. This project aims to 1) test the ability of drug pairs with opposing selection forces to suppress resistance in vitro and 2) define the physiological and molecular basis of these opposing evolutionary forces.