Protection against Herpesvirus super-infection

疱疹病毒感染我们所有人，并导致癌症、失明和先天性残疾。研制疫苗需要来自患者和实验动物的信息。CD4 T细胞似乎直接抑制病毒复制，而鼻子中的细胞为疱疹病毒提供了一个重要的进入途径。我们将测试CD4 T细胞是否能清除鼻腔感染；他们识别哪些目标；以及他们的行为。因此，我们可以确定CD4 T细胞导向疫苗是否可以预防疾病。

Herpesviruses infect us all and cause cancer, blindness, and congenital disability. Developing vaccines requires information from both patients and experimental animals. CD4 T cells seem to suppress directly virus replication, and cells in the nose provide an important way for herpesviruses to get in. We will test whether CD4 T cells can clear nasal infection; what targets they recognize; and how they act. Thus we can establish whether CD4 T cell-directed vaccines might protect against disease.