Purine metabolism as an antifungal drug target

真菌病原体新型隐球菌每年导致多达100万人死亡，因此需要开发新的抗真菌药物。我们已经表征了GTP生物合成酶IMP脱氢酶，揭示了它对感染至关重要，结构和功能分析揭示了抑制剂特异性的途径。在拟议的工作中，将开发针对这种酶的新型抗真菌化合物，并研究相关酶作为潜在的未来药物靶点。

The fungal pathogen Cryptococcus neoformans is responsible for up to a million deaths annually, necessitating the development of novel antifungals. We have characterised the GTP biosynthesis enzyme IMP dehydrogenase, revealing it is critical for infection, and structural and functional analysis reveals routes to inhibitor specificity. In the proposed work will develop novel antifungal compounds that target this enzyme, as well as investigate related enzymes as potential future drug targets.