REBALANCING THE LEVELS OF CCL17 AND CCL22 TO IMPROVE RHEUMATOID ARTHRITIS

风湿性关节炎是炎症性疾病的最常见形式，导致生活质量差。本研究旨在探讨两种趋化因子CCL17和CCL22在关节炎发生发展中的表达和功能。使用关节炎小鼠模型和患者样本，我将提供新的理解，不仅这些趋化因子是如何调节的，而且它们在介导效应器功能中的作用。我将全面评估它们是否适合作为治疗目标。

Rheumatoid arthritis is the inflammatory disease's severest form, leading to poor quality of life. This study will investigate the expression and function of two chemokines, CCL17 and CCL22, in the development of arthritis. Using arthritis mouse models and patient samples, I will provide new understanding, not only of how these chemokines are regulated, but also of their role in mediating effector functions. I will comprehensively evaluate their suitability as treatment targets.