Reducing pertussis burden by optimising molecular epidemiological surveillance of epidemic Bordetella pertussis in Australia

澳大利亚从2008年到2012年经历了一次长期的百日咳疫情，目前正在经历另一场疫情。在这个项目中，我们的目标是通过基因组测序来阐明流行病的进化动力学，并开发一种实用的高通量、非培养条件的流行病学分型方法。研究结果将对监测百日咳感染和制定百日咳控制和预防策略具有重要意义。

Australia has experienced a prolonged epidemic of pertussis from 2008 to 2012 and is currently experiencing another epidemic. In this project, we aim to elucidate the evolutionary dynamics of the epidemics by genome sequencing and develop a practical high throughput culture independent method for epidemiological typing. The outcomes will be highly significant for surveillance of pertussis infections and designing strategies for control and prevention of pertussis.