Analysing the immune response and optimising the effectiveness of Mesothelin CAR T-cell therapy in cancer.

嵌合抗原受体（CAR） t细胞将工程受体附着在患者的免疫细胞上。它们的目标是癌症，对健康细胞的损害风险较小。我们的实验室生产针对胰腺癌和其他癌症的肿瘤标志物-间皮素的CAR - t细胞。我计划在体外和小鼠中测试这些CAR - t细胞，然后招募癌症患者进行CAR - t细胞的临床试验。我的目标是监测安全性、有效性，并帮助提高患者的生存和生活质量。

Chimeric Antigen Receptor (CAR) T-cells have engineered receptors attached to patient immune cells. They target cancer with less risk of damage to healthy cells. Our laboratory manufactures CAR T-cells targeting a tumour marker- mesothelin, found on pancreatic and other cancers. I plan to test these CAR T-cells in vitro and in mice followed by enrolling cancer patients in a clinical trial of CAR T-cells. My aim is to monitor safety, efficacy and help improve patient survival and quality of life.