Analysis of circulating tumour DNA for mutational characterisation and tracking disease progression in multiple myeloma

多发性骨髓瘤是骨髓中浆细胞的癌症，并在多个部位呈现不同的遗传信息（GI）。需要对多个部位进行侵入性活检以确定GI。癌细胞将少量DNA脱落到血流中，这种循环DNA（ctDNA）包含来自多个癌症部位的GI。该项目将评估ctDNA在确定GI和预测MM患者治疗反应方面的效用。

Multiple myeloma is cancer of plasma cells in the bone marrow and presents at multiple sites with dissimilar genetic information (GI) across these sites. Invasive biopsies of multiple sites are required to determine the GI. Cancer cells shed small amounts of DNA into the blood stream and this circulating DNA (ctDNA) contains GI from multiple cancer sites. This project will evaluate the utility of ctDNA to determine GI and to predict treatment response in MM patients.