The complement cascade, cortical thinning and the development of psychosis

精神分裂症是一种复杂的疾病，对经历它的人来说会产生毁灭性的后果。尽管经过了一个多世纪的研究，我们仍然不清楚是什么生物因素影响了这种疾病。这项研究将调查免疫系统中一种特殊的成分，即补体蛋白，在精神分裂症患者的血液和大脑中的作用，以及它们如何影响患者的预后。这项研究将提高我们对精神分裂症涉及的生物学因素的理解。

Schizophrenia is a complex disorder with devastating consequences to those that experience it. Despite over a century of research we are still not clear what biological factors influence the disorder. This research will investigate the role of a specific component of the immune system, called complement proteins, in the blood and brain of schizophrenia patients and how they impact patient outcomes. This research will improve our understanding of the biological factors involved in schizophrenia.